Hyperinsulinemia for the development of hypertension: Data from the Hawaii-Los Angeles-Hiroshima study
Hyperinsulinemia for the development of hypertension: Data from the Hawaii-Los Angeles-Hiroshima study
复制标题
DOI：
10.1291/hypres.24.531
复制
发表时间：
2001-09-01
影响因子：
5.4
通讯作者：
Kohno, N
中科院分区：
文献类型：
--
作者：
Imazu, M;Yamamoto, H;Kohno, N
本研究旨在评估包括高胰岛素血症在内的代谢因素与日裔美国人高血压发展之间的关系。来自夏威夷-洛杉矶-广岛研究的 140 名年龄在 40 至 69 岁之间、血压正常（< 140/90 mmHg）的受试者被随访了 15 年。患有心血管疾病的患者被排除在外。分析基线、葡萄糖负荷后 1 小时和 2 小时的体重指数 (BMI)、血压 (BP)、血清总胆固醇 (TC)、甘油三酯 (TG)、尿酸 (UA) 以及葡萄糖和胰岛素反应。随访期间，17 名受试者出现高血压（收缩压大于或等于 160 mmHg，舒张压大于或等于 95 mmHg，或接受药物治疗）。后来患高血压的受试者的年龄和性别调整后的体重指数、血压、血清尿酸、甘油三酯、胰岛素以及随访期间空腹血糖的变化高于未患高血压的受试者。 BMI 的变化没有差异。根据 BMI、血清 UA、TG 的四分位数以及葡萄糖负荷期间胰岛素值总和（西格玛胰岛素），经年龄和性别调整后发生高血压的相对风险在分布的最高四分位数中最高。当年龄、性别、收缩压、BMI、血清UA、TC、TG、空腹血糖、Sigma胰岛素和BMI变化进行比例风险分析时，发现高胰岛素血症、高尿酸血症和收缩压是高血压的显着危险因素。总之，高胰岛素血症以及肥胖、高尿酸血症和高甘油三酯血症与日裔美国人的高血压有关。高胰岛素血症和高尿酸血症是高血压发生的独立预测因素。
The present study was to assess the association of metabolic factors including hyperinsulinemia, with the development of hypertension in Japanese-Americans. One hundred forty normotensive (< 140/90 mmHg) subjects aged 40 to 69 years old from the Hawaii-Los Angeles-Hiroshima study were followed for 15 years. Patients with cardiovascular disease were excluded. Body mass index (BMI), blood pressure (BP), serum total cholesterol (TC), tr[glycerides (TG), uric acid (UA), and glucose and insulin responses at baseline, 1 h, and 2 h after a glucose load were analyzed. Seventeen subjects became hypertensive (systolic BP greater than or equal to 160 mmHg, diastolic BP greater than or equal to 95 mmHg, or received drug treatment) during follow-up. Age- and sex-adjusted BMI, BP, serum UA, TG, insulin, and changes in fasting glucose during follow-up were higher in subjects who later became hypertensive than in those who did not. There was no difference in the change in BMI. Age- and sex-adjusted relative risks for the development of hypertension by quartiles of BMI, serum UA, TG, and the sum of insulin values (Sigma insulin) during a glucose load were highest in highest quartile of the distribution. When age, sex, systolic BP, BMI, serum UA, TC, TG, fasting glucose, Sigma insulin, and the change in BMI were used in a proportional hazard analysis, hyperinsulinemia, hyperuricemia, and systolic BP were found to be significant risk factors for hypertension. In conclusion, hyperinsulinemia, as well as obesity, hyperuricemia, and hypertriglyceridemia were associated with hypertension in Japanese-Americans. Hyperinsulinemia and hyperuricemia were independent predictors of the development of hypertension.