Increased prefrontal oxygenation prior to and at the onset of over-ground locomotion in humans
Increased prefrontal oxygenation prior to and at the onset of over-ground locomotion in humans
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人类地面运动之前和开始时前额氧合增加
DOI：
10.1152/japplphysiol.00392.2020
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发表时间：
2020
影响因子：
3.3
通讯作者：
Smith Scott A.
中科院分区：
文献类型：
--
作者：
Matsukawa Kanji;Asahara Ryota;Ishii Kei;Kunishi Mayo;Yamashita Yurino;Hashiguchi Yoshiki;Liang Nan;Smith Scott A.
我们的实验室通过近红外光谱 (NIRS) 报告称，作为区域脑血流量指数测量的前额氧合血红蛋白浓度 (Oxy-Hb) 在实验室环境中进行任意（即非提示）测力计运动之前和开始时有所增加。在当前的研究中，我们假设自然发生的地上运动，尽管“非常轻”的运动努力（如博格量表 8.0±0.3 所示）同样会导致前额皮质的运动前激活。在这项研究中，我们利用无线 NIRS 检测了 13 名受试者在任意行走之前前额活动发生变化的时间和程度。任意步行开始前 2 s 前额叶 Oxy-Hb 增加，步行开始 5 s 时增加的 Oxy-Hb 达到峰值。当根据提示被迫开始地面行走时，运动前和初始阶段前额叶氧合血红蛋白的增加不存在。任意开始和提示开始之间的 Oxy-Hb 响应差异被认为与中枢命令相关，在步行开始前 2 秒变得显着，比心率 (HR) 响应差异早 8 秒。这表明与 69% 受试者的心率差异呈正相关。同样，随意行走的意象能够将前额叶的氧合作用提高到与实际行走相同的程度。因此，尽管“非常轻”的努力，但在日常生活中自然发生的步行开始之前，前额叶氧合很可能会增加。前额叶氧合的增加可能至少部分有助于心脏调节，与运动表现的开始同步。新的和值得注意的我们使用无线近红外光谱发现，在任意地面行走开始之前，前额叶氧合增加，而当根据提示突然开始步行时，运动前的氧合不增加。启动模式之间的前额叶氧合差异（被认为与中枢命令有关）先于心率反应差异，并证明与心率差异呈正相关。与中枢命令相关的前额叶活动可能有助于心脏调节，与地面行走的开始同步。
Our laboratory has reported with near-infrared spectroscopy (NIRS) that prefrontal oxygenated-hemoglobin concentration (Oxy-Hb), measured as index of regional cerebral blood flow, increased before and at the onset of arbitrary (i.e., noncued) ergometer exercise in a laboratory environment. In the current study, we hypothesized that naturally occurring over-ground locomotion, despite “very light” motor effort, as indicated by a Borg scale of 8.0 ± 0.3, likewise causes preexercise activation of the prefrontal cortex. Using wireless NIRS, we examined in this study how early and to what extent prefrontal activity changed before the onset of arbitrary walking in 13 subjects. Prefrontal Oxy-Hb increased 2 s before the onset of arbitrary walking, and the increased Oxy-Hb reached a peak at 5 s from walking onset. The preexercise and initial increase in prefrontal Oxy-Hb was absent when over-ground walking was forced to start by cue. The difference in the Oxy-Hb response between arbitrary and cued start, which was considered to be related to central command, became significant 2 s before walking onset, preceding the difference in the heart rate (HR) response by 8 s. This demonstrated a positive relationship with the HR difference in 69% of subjects. Imagery of arbitrary walking was, likewise, able to increase prefrontal oxygenation to the same extent as actual walking. Thus, it is likely that prefrontal oxygenation increases before the onset of naturally occurring walking in daily life, despite “very light” effort. The increased prefrontal oxygenation may contribute at least partly to cardiac adjustment, synchronized with the beginning of motor performance.NEW & NOTEWORTHYWe found using wireless near-infrared spectroscopy that prefrontal oxygenation increased before the onset of arbitrary over-ground walking, whereas the preexercise increase was absent when walking was suddenly started by cue. The difference in prefrontal oxygenation between start modes (considered related to central command) preceded heart rate response variances and demonstrated a positive relationship with the difference in heart rate. The central command-related prefrontal activity may contribute to cardiac adjustment, synchronized with the beginning of over-ground walking.