Emergence of a unique group of necrotizing mycobacterial diseases
Emergence of a unique group of necrotizing mycobacterial diseases
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DOI：
10.3201/eid0503.990307
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发表时间：
1999-05-01
影响因子：
11.8
通讯作者：
King, CH
中科院分区：
文献类型：
--
作者：
Dobos, KM;Quinn, FD;King, CH
虽然大多数由致病性分枝杆菌引起的疾病是由结核分枝杆菌引起的，但其他几种分枝杆菌疾病-由分枝杆菌引起的。溃疡（布鲁里溃疡）、M. marinum和M.嗜血杆菌已经开始出现。我们回顾了过去十年中美国和世界各地由这三种病原体引起的疾病的出现。我们研究疾病的病理生理相似性（所有三个原因坏死性皮肤病变）和常见的感染水库（停滞或缓慢流动的水）。这些分枝杆菌的组织学和致病特征的检查表明，在传播和发病机制的模式的差异，虽然没有单一的机制，任何这些分枝杆菌的特征已被明确描述。
Although most diseases due to pathogenic mycobacteria are caused by Mycobacterium tuberculosis, several other mycobacterial diseases-caused by M. ulcerans (Buruli ulcer), M. marinum, and M. haemophilum-have begun to emerge. We review the emergence of diseases caused by these three pathogens in the United States and around the world in the last decade. We examine the pathophysiologic similarities of the diseases (all three cause necrotizing skin lesions) and common reservoirs of infection (stagnant or slow-flowing water). Examination of the histologic and pathogenic characteristics of these mycobacteria suggests differences in the modes of transmission and pathogenesis, though no singular mechanism for either characteristic has been definitively described for any of these mycobacteria.