Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis
Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis
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DOI：
10.1016/j.colsurfb.2010.04.014
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Gurunathan, Sangiliyandi
中科院分区：
文献类型：
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作者：
Kalishwaralal, Kalimuthu;BarathManiKanth, Selvaraj;Gurunathan, Sangiliyandi
生物膜是由于细菌附着在表面并聚集在水合聚合物基质中而产生的。这些固着群落的形成及其对抗菌剂的固有抗性是许多无情和慢性细菌感染的来源。这种生物膜在人类眼部相关感染性疾病即微生物角膜炎的发展中起主要作用。不同的方法已被用于预防卫生保健环境中的生物膜相关感染。这些方法中的许多方法具有其自身的缺点，包括基于化学的并发症：出现的抗生素抗性菌株等。银纳米颗粒以其有影响力的抗微生物活性而闻名。因此，本研究在生物合成的银纳米颗粒上，表现出潜在的抗生物膜活性，其在体外对铜绿假单胞菌和表皮葡萄球菌在24小时处理期间形成的生物膜进行测试。用银纳米颗粒处理这些生物体导致超过95%的生物膜形成抑制。已知抑制作用在供试种属中不变。因此，本研究证明了银纳米颗粒在基于其潜在的抗生物膜活性治疗微生物角膜炎中的未来应用。(C)2010 Elsevier B.V.保留所有权利。
Biofilms are ensued due to bacteria that attach to surfaces and aggregate in a hydrated polymeric matrix. Formation of these sessile communities and their inherent resistance to anti-microbial agents are the source of many relentless and chronic bacterial infections. Such biofilms are responsible play a major role in development of ocular related infectious diseases in human namely microbial keratitis. Different approaches have been used for preventing biofilm related infections in health care settings. Many of these methods have their own demerits that include chemical based complications: emergent antibiotic resistant strains, etc. silver nanoparticles are renowned for their influential anti-microbial activity. Hence the present study over the biologically synthesized silver nanoparticles, exhibited a potential anti-biofilm activity that was tested in vitro on biofilms formed by Pseudomonas aeruginosa and Staphylococcus epidermidis during 24-h treatment. Treating these organisms with silver nanoparticles resulted in more than 95% inhibition in biofilm formation. The inhibition was known to be invariable of the species tested. As a result this study demonstrates the futuristic application of silver nanoparticles in treating microbial keratitis based on its potential anti-biofilm activity. (C) 2010 Elsevier B.V. All rights reserved.