Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains
Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains
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DOI：
10.1194/jlr.m500073-jlr200
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发表时间：
2005-08-01
影响因子：
6.5
通讯作者：
Cheverud, JM
中科院分区：
文献类型：
--
作者：
Jarvis, JP;Kenney-Hunt, J;Cheverud, JM
母亲对后代表型的影响发生，因为许多物种的母亲为其发育中的年轻人提供了环境。虽然这些因素是正确的“环境”方面的后代基因组，其差异可能有遗传和环境的基础上，在母系。在这里，C57 BL/6 J和10 LGXSM重组近交系（RI）株之间的正反交进行，并在断奶窝分为高脂肪和低脂肪的饮食治疗。相互窝之间的差异被用来衡量后代表型遗传母体的影响。几乎所有的性状，包括每周的体重和成人血清性状，显示的影响表明遗传变异的母体影响跨RI株，允许涉及的数量性状基因座进行映射。虽然许多关于母体效应的文献与早期生命特征有关，但我们检测到了对成年期测量的特征的强烈而显著的母体效应（断奶后17周或更长时间的特征方差高达10%）。我们还发现了一个相互作用，影响成人表型之间的RI株母亲和C57 BL/6 J母亲和后来的环境因素（膳食脂肪摄入量）的影响，一些特定年龄的重量之间的孕产妇保健。
Maternal effects on offspring phenotypes occur because mothers in many species provide an environment for their developing young. Although these factors are correctly "environmental" with respect to the offspring genome, their variance may have both a genetic and an environmental basis in the maternal generation. Here, reciprocal crosses between C57BL/6J and 10 LGXSM recombinant inbred ( RI) strains were performed, and litters were divided at weaning into high-fat and low-fat dietary treatments. Differences between reciprocal litters were used to measure genetic maternal effects on offspring phenotypes. Nearly all traits, including weekly body weights and adult blood serum traits, show effects indicative of genetic variation in maternal effects across RI strains, allowing the quantitative trait loci involved to be mapped. Although much of the literature on maternal effects relates to early life traits, we detect strong and significant maternal effects on traits measured at adulthood ( as much as 10% of the trait variance at 17 or more weeks after weaning). We also found an interaction affecting adult phenotype between the effects of maternal care between RI strain mothers and C57BL/6J mothers and a later environmental factor ( dietary fat intake) for some age-specific weights.