ANTIOXIDANT EFFECT OF MANGANESE
ANTIOXIDANT EFFECT OF MANGANESE
复制标题
DOI：
10.1016/0003-9861(92)90282-2
复制
发表时间：
1992-12-01
影响因子：
3.9
通讯作者：
BINDOLI, A
中科院分区：
文献类型：
--
作者：
COASSIN, M;URSINI, F;BINDOLI, A
研究了锰和其他过渡金属的抗氧化作用，如抑制微粒体脂质过氧化和过氧化氢自由基对藏红花素的漂白作用。采用竞争动力学方法测定其清除过氧化氢自由基的能力。虽然Zn（II）、Ni（II）和Fe（II）几乎完全无效，但Mn（II）和Co（II）显示出自由基清除能力，表现出相对速率常数比分别为0.513和0.287。这表明Mn（II）是迄今为止最活跃的。因此，Mn（II）的断链抗氧化能力可能与反应R-OO · + Mn（II）+ H+→ ROOH + Mn（III）中过氧自由基的快速淬灭有关。考虑到不同的还原电位的检查阳离子的抗氧化剂的机制进行了讨论。
The antioxidant effects of manganese and other transition metals were studied as the inhibition of microsomal lipid peroxidation and crocin bleaching by peroxyl radicals. The peroxyl radical scavenging capacity was measured by competition kinetics analysis. While Zn(II), Ni(II), and Fe(II) were almost completely ineffective, Mn(II) and Co(II) showed a free radical scavenging capacity, exhibiting relative rate constant ratios respectively of 0.513 and 0.287. This indicates that Mn(II) is by far the most active. Therefore, the chain-breaking antioxidant capacity of Mn(II) seems to be related to the rapid quenching of peroxyl radicals according to the reaction R-OO · + Mn(II) + H+→ ROOH + Mn(III). The antioxidant mechanism is discussed considering the different reduction potentials of the examined cations.