INSULIN-RECEPTORS IN ACUTE INFECTION - A STUDY OF FACTORS CONFERRING INSULIN RESISTANCE
INSULIN-RECEPTORS IN ACUTE INFECTION - A STUDY OF FACTORS CONFERRING INSULIN RESISTANCE
复制标题
DOI：
10.1210/jcem-58-4-710
复制
发表时间：
1984-01-01
影响因子：
5.8
通讯作者：
BAUMANN, G
中科院分区：
文献类型：
--
作者：
DROBNY, EC;ABRAMSON, EC;BAUMANN, G
急性感染伴有组织胰岛素抵抗，表现为糖尿病患者代谢控制恶化，非糖尿病受试者糖耐量下降。为了阐明胰岛素受体状态改变在这一现象中的潜在作用，研究了7名健康受试者在中度严重的急性细菌和病毒感染期间[125I]胰岛素与单核细胞的结合。将其与恢复期(5例)和24例正常受试者进行比较。感染期间的胰岛素结合，在胰岛素抵抗明显的时候，与恢复期或正常值没有区别。感染期间血糖和胰岛素水平、胰岛素/葡萄糖比值以及血浆生长激素、皮质醇和游离脂肪酸显著升高，而血浆胰高血糖素、肾上腺素和去甲肾上腺素水平正常。就单核细胞受体代表其他组织而言，感染时的胰岛素抵抗显然是在受体后水平上调节的。
Acute infections are accompanied by tissue insulin resistance, as manifested by worsening of metabolic control in diabetic patients and decreased glucose tolerance in non-diabetic subjects. To clarify the potential role of altered insulin receptor status in this phenomenon, [125I]insulin binding to monocytes was studied in 7 otherwise healthy subjects during acute bacterial and viral infections of moderate severity. The values were compared to those obtained after convalescence (5 patients) and those of 24 normal subjects. Insulin binding during infection, at a time when insulin resistance was demonstrable, was indistinguishable from convalescent or normal values. Plasma glucose and insulin levels, the insulin to glucose ratio, as well as plasma growth hormone, cortisol and free fatty acids were significantly elevated during infection, while plasma glucagon, epinephrine and norepinephrine levels were normal. Insofar as monocyte receptors are representative of other tissues, insulin resistance in infection apparently is mediated at the postreceptor level.