From Metabolism to Ecology: Cross-Feeding Interactions Shape the Balance between Polymicrobial Conflict and Mutualism
From Metabolism to Ecology: Cross-Feeding Interactions Shape the Balance between Polymicrobial Conflict and Mutualism
复制标题
DOI：
10.1086/667887
复制
发表时间：
2012-11-01
影响因子：
2.9
通讯作者：
Brown, Sam P.
中科院分区：
文献类型：
--
作者：
Estrela, Sylvie;Trisos, Christopher H.;Brown, Sam P.
多微生物相互作用在自然界广泛存在，在维持人类健康和生态系统方面发挥着重要作用。当一种生物利用另一种生物产生的代谢物作为能量或营养来源时，称为交叉饲养。交叉喂养相互作用的生态结果知之甚少，并且可能多种多样：互惠、竞争、剥削或共生。造成这种不确定性的一个主要原因是缺乏将微生物代谢与微生物生态学联系起来的理论方法。为了解决这个问题，我们探索了一种单向种间交叉喂养相互作用的动力学，在这种相互作用中，食物可以被交换为一种服务（解毒）。我们的研究结果表明，多种生态相互作用（竞争、互惠、开发）可以从这种简单的交叉喂养相互作用中产生，并且可以通过控制关联成本和收益平衡的代谢、人口统计学和环境参数来预测。特别是，我们的模型预测了中间副产物毒性更强的互惠关系，因为资源-服务交换受到限制，服务既不是太重要（高毒性损害资源供应），也不是可有可无（低毒性减少对服务的需求）。这些结果支持这样一种观点，即连接微生物生态学和代谢是更好地理解控制多微生物相互作用出现和动态的因素的关键一步。
Polymicrobial interactions are widespread in nature and play a major role in maintaining human health and ecosystems. Whenever one organism uses metabolites produced by another organism as energy or nutrient sources, it is called cross-feeding. The ecological outcomes of cross-feeding interactions are poorly understood and potentially diverse: mutualism, competition, exploitation, or commensalism. A major reason for this uncertainty is the lack of theoretical approaches linking microbial metabolism to microbial ecology. To address this issue, we explore the dynamics of a one-way interspecific cross-feeding interaction in which food can be traded for a service (detoxification). Our results show that diverse ecological interactions (competition, mutualism, exploitation) can emerge from this simple cross-feeding interaction and can be predicted by the metabolic, demographic, and environmental parameters that govern the balance of the costs and benefits of association. In particular, our model predicts stronger mutualism for intermediate by-product toxicity because the resource-service exchange is constrained to the service being neither too vital (high toxicity impairs resource provision) nor dispensable (low toxicity reduces need for service). These results support the idea that bridging microbial ecology and metabolism is a critical step toward a better understanding of the factors governing the emergence and dynamics of polymicrobial interactions.