Contribution of Sickle Cell Disease to the Pediatric Stroke Burden Among Hospital Discharges of African-Americans-United States, 1997-2012.
Contribution of Sickle Cell Disease to the Pediatric Stroke Burden Among Hospital Discharges of African-Americans-United States, 1997-2012.
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DOI：
10.1002/pbc.25655
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发表时间：
2015-12
影响因子：
3.2
通讯作者：
Adamkiewicz TV
中科院分区：
文献类型：
--
作者：
Baker C;Grant AM;George MG;Grosse SD;Adamkiewicz TV
大约10%-20%的镰状细胞病(SCD)儿童患上中风，但几乎没有一致的国家估计SCD儿童的中风负担。这项研究的目的是确定患有和不患有SCD的非裔美国人出院儿童中被诊断为中风的比例。包括1997年至2012年儿童住院数据库(KID)中1-18岁非裔美国人的中风诊断代码为≥1ICD-9-CM的记录。对数据进行了加权，以提供国家估计。在非洲裔美国儿童中总共发现了2994例中风病例。合并缺血性卒中或出血性卒中的诊断频率分别排名。从1997年到2012年，24%的卒中患者中存在SCD，其中89%是缺血性卒中。对于出院的非裔美国儿童来说，SCD是缺血性中风的最高共存危险因素(29%)。SCD儿童的卒中主要发生在5-9岁的儿童中，比以前报道的年龄更大。从1997年到2012年，SCD儿童卒中放电的趋势在10-14岁儿童中显著减少。SCD是非裔美国儿童中儿童中风的主要危险因素。减少SCD儿童的中风数量将对非裔美国儿童的中风发生率产生重大影响。预防性干预可能会改变SCD儿童卒中的初始年龄。
Approximately 10–20% of children with sickle cell disease (SCD) develop stroke, but few consistent national estimates of the stroke burden for children with SCD exist. The purpose of this study is to determine the proportion of diagnosed stroke among African-American pediatric discharges with and without SCD. Records for African-Americans aged 1–18 years in the Kids' Inpatient Database (KID) 1997–2012 with ≥1 ICD-9-CM diagnosis code for stroke were included. Data were weighted to provide national estimates. A total of 2,994 stroke cases among African-American children were identified. Diagnoses co-existing with ischemic or hemorrhagic stroke were frequency ranked separately. From 1997 through 2012, SCD was present in 24% of stroke discharges, with 89% being ischemic stroke. For hospital discharges of African-American children, SCD is the highest co-existing risk factor for ischemic stroke (29%). Stroke in children with SCD occurred predominantly in children aged 5–9 years, older than previously reported. The trend of stroke discharges significantly decreased for children with SCD from 1997 to 2012 for children aged 10–14 years. SCD is a leading risk factor to pediatric stroke in African-American children. Reducing the number of strokes among children with SCD would have a significant impact on the rate of strokes among African-American children. Preventative intervention may be modifying initial age of presentation of stroke in children with SCD.