ASSOCIATION BETWEEN BLOOD-PRESSURE AND SERUM-LIPIDS IN A POPULATION - THE TROMSO STUDY
ASSOCIATION BETWEEN BLOOD-PRESSURE AND SERUM-LIPIDS IN A POPULATION - THE TROMSO STUDY
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DOI：
10.1161/01.cir.83.4.1305
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发表时间：
1991-04-01
期刊：
影响因子：
37.8
通讯作者：
THELLE, DS
中科院分区：
文献类型：
--
作者：
BONAA, KH;THELLE, DS
背景。高血压与动脉粥样硬化性血脂含量升高有关，但流行病学调查在人群亚组中往往给出不一致的结果。更好地了解血压和血脂之间的关系可能有助于深入了解高血压与冠心病风险增加相关的机制。方法与结果。我们评估了8081名20-54岁男性和7663名20-49岁女性的血清总胆固醇、高密度脂蛋白（HDL）胆固醇、非高密度脂蛋白胆固醇（总减去HDL胆固醇）和甘油三酯水平与血压的横断面关系。分层分析和多变量方法用于控制潜在的混淆人体测量和生活方式变量。无论男女，总胆固醇和非高密度脂蛋白胆固醇水平都随着收缩压或舒张压的升高而显著升高。20-29岁男性的血压与总胆固醇水平的回归斜率比同龄女性更陡。在男性中，血压和总胆固醇水平之间的关系随着年龄的增长而减弱，而在女性中，这种关系随着年龄的增长而增强。身体质量指数修正了这一关系，而吸烟、体育活动和饮酒对这一关系的影响很小。甘油三酯水平随血压升高而升高，但这种关系在瘦受试者中较弱。在高饮酒量人群亚群中，高密度脂蛋白胆固醇水平与血压呈正相关。这些结果支持了血压和血脂之间存在生物学相互关系的假设，这可能会影响血压与冠心病风险相关的机制。
Background. High blood pressure has been associated with elevated atherogenic blood lipid fractions, but epidemiological surveys often give inconsistent results across population subgroups. A better understanding of the relation between blood pressure and blood lipids may provide insight into the mechanism(s) whereby hypertension is associated with increased risk of coronary heart disease.Methods and Results. We assessed the cross-sectional relations of serum total cholesterol, high density lipoprotein (HDL) cholesterol, non-HDL cholesterol (total minus HDL cholesterol), and triglyceride levels with blood pressure in a population of 8,081 men 20-54 years old and 7,663 women 20-49 years old. Stratified analyses and multivariable methods were used to control for potential confounding anthropometric and lifestyle variables. Total and non-HDL cholesterol levels increased significantly with increasing systolic or diastolic blood pressure in both sexes. Men 20-29 years old had steeper regression slopes for blood pressure by total cholesterol level than did women of similar age. In men, the association between blood pressure and total cholesterol level decreased with age, whereas in women, it increased with age. Body mass index modified the relation, whereas smoking, physical activity, and alcohol consumption had little influence on the association. Triglyceride levels increased with blood pressure, but this relation was weak in lean subjects. HDL cholesterol level correlated positively with blood pressure in population subgroups having a high alcohol consumption.Conclusion. These results support the hypothesis that there are biological interrelations between blood pressure and blood lipids that may influence the mechanisms whereby blood pressure is associated with risk of coronary heart disease.