LOW 2ND TRIMESTER MATERNAL SERUM UNCONJUGATED ESTRIOL IN PREGNANCIES WITH DOWNS-SYNDROME
LOW 2ND TRIMESTER MATERNAL SERUM UNCONJUGATED ESTRIOL IN PREGNANCIES WITH DOWNS-SYNDROME
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DOI：
10.1111/j.1471-0528.1988.tb06601.x
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发表时间：
1988-04-01
期刊：
影响因子：
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通讯作者：
WALD, NJ
中科院分区：
文献类型：
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作者：
CANICK, JA;KNIGHT, GJ;WALD, NJ
对22例与唐氏综合征相关的妊娠和110例未受影响的对照妊娠的储存血清样品中孕中期母体血清非结合雌三醇水平进行了测量，这些样品与母体年龄、胎龄、血清样品储存时间、吸烟习惯和母体体重相匹配。每个受影响妊娠的血清未结合雌三醇水平表示为其5个匹配对照的中位数（MoM）的倍数。未结合雌三醇水平在受累妊娠中显著低于未受累妊娠;中位数MoM为0.79（P < 0.05）。妊娠早期低血清非结合雌三醇与胎儿唐氏综合征之间的这种关联，提出了在产前唐氏综合征筛查中，血清非结合雌三醇测量可以添加到母亲年龄和甲胎蛋白测量中的可能性。
Second trimester maternal serum unconjugated oestriol levels were measured in the stored serum samples from 22 pregnancies associated with Down''s syndrome and 110 unaffected control pregnancies, matched for maternal age, gestational age, duration of storage of the serum sample, smoking habits and maternal weight. The serum unconjugated oestriol level of each affected pregnancy was expressed as a multiple of the median (MoM) of its five matched controls. The unconjugated oestriol levels were significantly lower in the affected pregnancies than in the unaffected pregnancies; the median MoM was 0.79 (P < 0.05). This association between low serum unconjugated oestriol and fetal Down''s syndrome early in pregnancy raises the possibility that serum unconjugated oestriol measurement may be added to maternal age and alpha-fetoprotein measurement in the antenatal screening for Down''s syndrome.