N-trifluoroacetyl sialyl phosphite donors for the synthesis of α(2 → 9) oligosialic acids
N-trifluoroacetyl sialyl phosphite donors for the synthesis of α(2 → 9) oligosialic acids
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DOI：
10.1021/ol0515210
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发表时间：
2005-09-15
期刊：
影响因子：
5.2
通讯作者：
Lin, CC
中科院分区：
文献类型：
--
作者：
Lin, CC;Huang, KT;Lin, CC
A new method for the synthesis of alpha(2 -> 9) oligosialic acids is developed using phosphite sialyl donors that are protected with a C-5 N-trifluoroacetyl (NHTFA) substituent. Compared with conventional donors, these donors gave a higher degree of alpha-anomeric selectivity during glycosidic bond formation and better yields during iterative sialylation in the synthesis of oligosialic acids.
