In vitro and in vivo studies on antithrombogenicity of poly(propylene oxide) segmented nylon 610 in relation to its crystalline-amorphous micpostructure
In vitro and in vivo studies on antithrombogenicity of poly(propylene oxide) segmented nylon 610 in relation to its crystalline-amorphous micpostructure
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聚环氧丙烷嵌段尼龙 610 与其晶态-非晶态微结构相关的抗血栓形成的体外和体内研究
DOI：
10.1016/0142-9612(88)90088-9
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
N. Ogata
中科院分区：
文献类型：
--
作者：
N. Yui;K. Kataoka;Y. Sakurai;T. Aoki;K. Sanui;N. Ogata
本文研究了聚环氧丙烷嵌段尼龙610的体外和体内抗血栓性。为了在体外模拟共聚物表面的血栓形成，改进的微球柱法评价了共聚物柱的血栓形成时间。为了体内评价共聚物表面的抗血栓形成性，将预涂有共聚物的小直径管植入家兔体内作为动静脉分流，以确定共聚物管的通畅时间。在体外和体内试验中，具有特定尺寸和分布的结晶和非晶微相的共聚物表现出优异的抗血栓性，具有约12 nm长周期和6.5 nm微晶厚度的共聚物抑制粘附血小板的活化过程，表现出抗血栓性。本文强调了半结晶微结构聚合物表面的抗凝血性的重要性，控制结晶-非晶微结构。
In vitroandin vivoantithrombogenicity of poly(propylene oxide) segmented nylon 610 was investigated. For thein vitrosimulation of thrombosis on copolymer surfaces, a modified microsphere column method evaluated the thrombosis time of the copolymer column. For thein vivoevaluation of the antithrombogenicity of copolymer surfaces, small diameter tubing, precoated with copolymer, was implanted in rabbits as an arteriovenous shunt to determine the time of patency for the copolymer tubing. In both thein vitroandin vivotests, the copolymer having a particular size and distribution of crystalline and amorphous microphases on its surface exhibited excellent antithrombogenicity; the copolymer with a long period of approximately 12 nm and a crystallite thickness of 6.5 nm suppressed the activation process of adhering platelets to show thromboresistant property. This paper emphasizes the importance of controlling the crystalline-amorphous microstructure for the antithrombogenicity of polymer surfaces with a semicrystalline microstructure.