[Specific inhibitory effects of hybrid liposomes on the growth of various tumor cells].
[Specific inhibitory effects of hybrid liposomes on the growth of various tumor cells].
复制标题
杂化脂质体对多种肿瘤细胞生长的特异性抑制作用。
DOI：
10.1248/yakushi1947.119.4_280
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
R. Ueoka
中科院分区：
文献类型：
--
作者：
Y. Matsumoto;T. Kato;S. Iseki;H. Suzuki;K. Nakano;R. Ueoka
由具有多种头部基团的脂质组成的杂化脂质体的抑制作用（两性离子L-α-二肉豆蔻酰磷脂酰胆碱（DMPC）、阴离子L-α-二肉豆蔻酰磷脂酰甘油（DMPG）和阳离子1，2-二肉豆蔻酰-3-三甲基铵丙烷（DMTAP））和聚氧乙烯（10）十二烷基醚（C12（EO）10）对肿瘤细胞生长的影响对人肺癌（RERF-LC-OK）、人肝癌（Hep-G2）、人胃肿瘤（GT 3 TKB）进行了体外检测。DMPC/10 mol% C12（EO）10和DMPG/10 mol% C12（EO）10的混合脂质体与脂质体（DMPC和DMPG）或胶束（C12（EO）10）相比，对本研究中使用的所有肿瘤细胞的生长具有相当高的抑制效果。特别是首次获得了DMPG/10 mol% C12（EO）10不含任何抗肿瘤药物的杂化脂质体对RERF-LC-OK和GT3 TKB生长的高度特异性抑制作用。
The inhibitory effects of hybrid liposomes composed of lipids having a variety of head groups (zwitterionic L-alpha-dimyristoylphosphatidylcholine (DMPC), anionic L-alpha-dimyristoylphosphatidylglycerol (DMPG), and cationic 1,2-dimyristoyl-3-trimethylammonium propane (DMTAP)) and polyoxyethylene (10) dodecyl ether (C12(EO)10) on the growth of tumor cells (human lung carcinoma (RERF-LC-OK), human hepatoma (Hep-G2), human stomach tumor (GT3TKB)) in vitro were examined. The hybrid liposomes of DMPC/10 mol% C12(EO)10 and DMPG/10 mol% C12(EO)10 were fairly more effective for inhibiting the growth of all tumor cells employed in this study as compared with liposomes (DMPC and DMPG) or micelles (C12(EO)10). Especially, it is attractive that the highly specific inhibitory effect of the hybrid liposomes of DMPG/10 mol% C12(EO)10 without any antitumor drugs on the growth of RERF-LC-OK and GT3TKB was obtained for the first time.