DNA information: from digital code to analogue structure
DNA information: from digital code to analogue structure
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DNA信息：从数字代码到模拟结构
DOI：
10.1098/rsta.2011.0231
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
And J M T Thompson
中科院分区：
文献类型：
--
作者：
A. A. Travers;G. Muskhelishvili;And J M T Thompson
DNA双螺旋中的碱基对所携带的数字线性编码，现在已知有一个重要的组成部分，它通过改变分子的长度、自然形状和刚度来起作用。通过这种方式，DNA的一个区域在结构上与另一个区域区别开来，构成了三维空间中编码信息的额外形式。这些形状和刚度的变化有助于指导和促进DNA在其三维空间相互作用。这种与自身的相互作用允许基因之间的交流，增强核小体核心颗粒内的包裹和组蛋白八聚体结合。同时，由于有利的序列依赖性弯曲各向异性，与蛋白质的相互作用可以减少熵结合惩罚。DNA内部序列的周期性，赋予了相应的形状和刚度的结构周期性，也影响了分子的超卷曲，这反过来又起着重要的促进作用。实际上，超螺旋密度作为一种模拟调节模式，而不是更普遍承认的纯数字模式。这些观点中有许多仍然没有得到很好的理解，它们代表了一个基本的、突出的生物学问题。这篇综述概述了最近的发展，并希望确定有希望的未来调查线。
The digital linear coding carried by the base pairs in the DNA double helix is now known to have an important component that acts by altering, along its length, the natural shape and stiffness of the molecule. In this way, one region of DNA is structurally distinguished from another, constituting an additional form of encoded information manifest in three-dimensional space. These shape and stiffness variations help in guiding and facilitating the DNA during its three-dimensional spatial interactions. Such interactions with itself allow communication between genes and enhanced wrapping and histone–octamer binding within the nucleosome core particle. Meanwhile, interactions with proteins can have a reduced entropic binding penalty owing to advantageous sequence-dependent bending anisotropy. Sequence periodicity within the DNA, giving a corresponding structural periodicity of shape and stiffness, also influences the supercoiling of the molecule, which, in turn, plays an important facilitating role. In effect, the super-helical density acts as an analogue regulatory mode in contrast to the more commonly acknowledged purely digital mode. Many of these ideas are still poorly understood, and represent a fundamental and outstanding biological question. This review gives an overview of very recent developments, and hopefully identifies promising future lines of enquiry.
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影响因子：
5.6
作者：
Czapla L;Peters JP;Rueter EM;Olson WK;Maher LJ 3rd
通讯作者：
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DOI：
10.1039/b901646e
发表时间：
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期刊：
Physical chemistry chemical physics : PCCP
影响因子：
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作者：
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作者：
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