Effect of subtype-selective opioid receptor blockers on nitrous oxide antinociception in rats.
Effect of subtype-selective opioid receptor blockers on nitrous oxide antinociception in rats.
复制标题
亚型选择性阿片受体阻滞剂对大鼠笑气镇痛作用的影响。
DOI：
10.1016/1043-6618(90)90733-t
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发表时间：
1990
影响因子：
9.3
通讯作者：
Chen,DC
中科院分区：
文献类型：
--
作者：
Quock,RM;Walczak,CK;Henry,RJ;Chen,DC
用不同阿片受体亚型的阻断剂预处理大鼠，通过温水尾戒断试验评价一氧化二氮的抗伤害作用。MR-2266（对κ-阿片受体具有相对选择性）显著升高了一氧化二氮抗伤害作用的镇痛剂量50%（AD 50）值，ICI-174，864（对δ-阿片受体具有选择性）升高程度较小。然而，即使在极高的剂量下，β-funaleamine（对μ-阿片受体具有选择性）预处理也不能改变一氧化二氮抗伤害作用的AD 50。根据这些发现，在该范例中评估的一氧化二氮抗伤害感受似乎是由κ-和可能的δ-阿片受体介导的，但不是μ-阿片受体。
Nitrous oxide antinociception in rats was evaluated by the warm water tail withdrawal test following central pretreatment with blockers of various opioid receptor subtypes. The analgesic dose, 50% (AD50) value for nitrous oxide antinociception was significantly elevated by MR-2266 (which is relatively selective for κ-opioid receptors) and increased to a lesser degree by ICI-174,864 (which is selective for δ-opioid receptors). However, pretreatment with β-funaltrexamine (which is selective for μ-opioid receptors), even at extremely high doses, was ineffective in altering the AD50for nitrous oxide antinociception. According to these findings, nitrous oxide antinociception, as evaluated in this paradigm, appears to be mediated by κ- and possibly δ- but not μ-opioid receptors.