Brain-gut-microbiota axis: challenges for translation in psychiatry
Brain-gut-microbiota axis: challenges for translation in psychiatry
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DOI：
10.1016/j.annepidem.2016.02.008
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发表时间：
2016-05-01
影响因子：
5.6
通讯作者：
Dinan, Timothy G.
中科院分区：
文献类型：
--
作者：
Kelly, John R.;Clarke, Gerard;Dinan, Timothy G.
目的：将肠道微生物群与中枢神经系统的发育和功能联系起来的积累数据已被提出作为神经科学的范式转变。肠道微生物群可以通过神经免疫、神经内分泌和包括脑-肠-微生物群轴的神经通路与大脑交流。功能失调的神经免疫通路与压力相关的精神疾病有关。方法：以抑郁症为例，我们回顾了支持肠道微生物群在压力相关精神疾病中可能发挥作用的临床前和临床证据。我们将考虑如何为未来的治疗策略提供信息，并概述推动该领域向前发展的挑战和必要的研究。结果：肠道微生物群在精神病人群中的作用尚未完全阐明。尽管人们很容易推测精神病患者可能受益于脑-肠-微生物群轴的治疗性调节，但在啮齿动物研究中获得的结果的转化应用尚未得到证实。结论：精神病患者肠道微生物群组成和功能改变的证据有限，不能被视为证实。此外，靶向肠道微生物群的功效尚未确定，需要进一步研究。(C) 2016 Elsevier Inc.版权所有。
Purpose: The accruing data linking the gut microbiome to the development and function of the central nervous system has been proposed as a paradigm shift in neuroscience. The gut microbiota can communicate with the brain via neuroimmune, neuroendocrine, and neural pathways comprising the brain-gut-microbiota axis. Dysfunctional neuroimmune pathways are implicated in stress-related psychiatric disorders.Methods: Using depression as our primary example, we review both the preclinical and clinical evidence supporting the possible role played by the gut microbiota in stress-related psychiatric disorders. We consider how this can inform future treatment strategies and outline the challenges and necessary studies for moving the field forward.Results: The role played by the gut microbiota has not been fully elucidated in psychiatric populations. Although tempting to speculate that psychiatric patients may benefit from therapeutic modulation of the brain-gut-microbiota axis, the translational applications of the results obtained in rodent studies have yet to be demonstrated.Conclusions: Evidence of altered gut microbiota composition and function in psychiatric patients is limited and cannot be regarded as proven. Moreover the efficacy of targeting the gut microbiota has not yet been established, and needs further investigation. (C) 2016 Elsevier Inc. All rights reserved.