Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003:: methods and characterization of participants
Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003:: methods and characterization of participants
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DOI：
10.1007/s00038-005-4075-5
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Leuenberger, P
中科院分区：
文献类型：
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作者：
Ackermann-Liebrich, U;Kuna-Dibbert, B;Leuenberger, P
目的：瑞士空气污染与成人肺部疾病的队列研究（SAPALDIA）旨在调查长期暴露于空气污染对健康的影响。招募时（1991年）和第一次重新评估时（2001- 2003年）的健康评估包括关于呼吸系统健康、职业和其他暴露、肺活量测定、乙酰甲胆碱支气管激发试验、呼气末一氧化碳（CO）测量和特应性测量。建立了一个DNA和血液标志物生物库。随机抽取50岁及以上的受试者，采用24小时心电图（霍尔特）测量心率变异性。自1991年起，我们已在所有研究范围内监测空气中二氧化氮、二氧化硫、臭氧和微粒的浓度。在11年的随访期间收集的住宅历史，再加上GIS建模将提供个人长期的空气污染物暴露estimations.Results：在1991年检查的9651名参与者，8715可以追溯到队列研究和283人死亡。获得了8047名受试者（86%的存活者）的健康状况基本信息，6528名受试者（70%）同意接受健康检查，5973名受试者（62%）完成了整个方案。重新评估的非参与者平均比参与者年轻，更有可能是吸烟者，并在第一次评估中报告了呼吸道症状。平均体重在11年内增加了5.5公斤，1991年重新评估时，28%的吸烟者已经戒烟。
Objectives: The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) was designed to investigate the health effects from long-term exposure to air pollution.Methods: The health assessment at recruitment (1991) and at the first reassessment (2001-3) consisted of an interview about respiratory health, occupational and other exposures, spirometry, a methacholine bronchial challenge test, end-expiratory carbon monoxide (CO) measurement and measurement for atopy. A bio bank for DNA and blood markers was established. Heart rate variability was measured using a 24-hour ECG (Holter) in a random sample of participants aged 50 years and older. Concentrations of nitrogen dioxide (NO2), sulphur dioxide (SO2), ozone (O-3) and particulates in ambient air have been monitored in all study areas since 1991. Residential histories collected over the 11 year follow-up period coupled with GIS modelling will provide individual long-term air pollutant exposure estimates.Results: Of 9651 participants examined in 1991, 8715 could be traced for the cohort study and 283 died. Basic information about health status was obtained for 8047 individuals (86 % of alive persons), 6528 individuals (70 %) agreed to the health examination and 5973 subjects (62 %) completed the entire protocol. Non-participants in the reassessment were on average younger than participants and more likely to have been smokers and to have reported respiratory symptoms in the first assessment. Average weight had increased by 5.5 kg in 11 years and 28% of smokers in 1991 had quit by the time of the reassessment.