Dietary flavonoid intakes and risk of type 2 diabetes in US men and women
Dietary flavonoid intakes and risk of type 2 diabetes in US men and women
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DOI：
10.3945/ajcn.111.028894
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发表时间：
2012-04-01
影响因子：
7.1
通讯作者：
van Dam, Rob M.
中科院分区：
文献类型：
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作者：
Wedick, Nicole M.;Pan, An;van Dam, Rob M.
背景：来自机制研究的数据支持特定黄酮类化合物对胰岛素敏感性的有益作用。然而，关于不同类黄酮摄入量与2型糖尿病的关系的研究却很少。目的：探讨膳食中主要类黄酮摄入量与2型糖尿病的关系。（即黄酮醇、黄酮、黄烷酮、黄烷-3-醇和花青素）与美国成年人患2型糖尿病的风险相关。设计：我们在护士健康研究中对70,359名女性进行了随访（NHS; 1984-2008年），89 201名妇女参加了国家卫生服务体系II（1991-2007年）和41，334名男性在卫生专业人员随访研究中结果：在3，645，585人-年的随访中，我们记录了12，611例2型糖尿病的发病病例。在对年龄、BMI、生活方式和饮食因素进行多变量调整后，花青素摄入量增加与2型糖尿病风险降低显著相关（3个队列的极端五分位数比较的合并HR：0.85; 95% CI：0.80，0.91; P趋势< 0.001）。食用富含花青素的食物，特别是蓝莓（合并HR：0.77，比较>= 2份/周与= 5份/周，
Background: Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes.Objective: The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults.Design: We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline.Results: During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P-trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0.77 from a comparison of >= 2 servings/wk with = 5 servings/wk with