Biosynthesis and Biotechnology of High-Value p-Menthane Monoterpenes, Including Menthol, Carvone, and Limonene
Biosynthesis and Biotechnology of High-Value p-Menthane Monoterpenes, Including Menthol, Carvone, and Limonene
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DOI：
10.1007/10_2014_289
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Lange, Bernd Markus
中科院分区：
文献类型：
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作者：
Lange, Bernd Markus
对薄荷烷族的单萜类化合物是广泛存在于植物界的挥发性次级(或专一)代谢物。它们是具有重要商业价值的精油的主要成分，这些精油来自薄荷属(藤科)、锦葵属(杏科)、柑橘属(十字花科)和桉树属(桃金娘科)。对薄荷烷单萜作为手性特种化学品也引起了人们的兴趣，因此从天然来源获得的产物还需要化学合成来补充。最近，已经开发了用于高水平积累特定目标单萜的微生物和植物平台。在这篇综述中，我讨论了与p-薄荷烷生物合成有关的基因和酶的性质，并对生物技术生产方法进行了关键的评估。
Monoterpenes of the p-menthane group are volatile secondary (or specialized) metabolites found across the plant kingdom. They are dominant constituents of commercially important essential oils obtained from members of the genera Mentha (Lamiaceae), Carum (Apiaceae), Citrus (Rutaceae), and Eucalyptus (Myrtaceae). p-Menthane monoterpenes have also attracted interest as chiral specialty chemicals, and the harvest from natural sources is therefore supplemented by chemical synthesis. More recently, microbial and plant-based platforms for the high-level accumulation of specific target monoterpenes have been developed. In this review chapter, I discuss the properties of the genes and enzymes involved in p-menthane biosynthesis and provide a critical assessment of biotechnological production approaches.