Comparative study of ovarian clear cell carcinoma with and without endometriosis in People's Republic of China
Comparative study of ovarian clear cell carcinoma with and without endometriosis in People's Republic of China
复制标题
中华人民共和国卵巢透明细胞癌伴子宫内膜异位症与不伴子宫内膜异位症的比较研究
DOI：
10.1016/j.fertnstert.2014.08.008
复制
发表时间：
2014-12-01
影响因子：
6.7
通讯作者：
Shen, Keng
中科院分区：
文献类型：
--
作者：
Ye, Shuang;Yang, Jiaxin;Shen, Keng
目的：分析和比较中国卵巢透明细胞癌（CCC）伴或不伴子宫内膜异位症患者的临床病理特征和预后。设计：基于病历回顾性分析的比较研究。地点：综合性大学医院。患者：2000年至2012年间诊断和治疗卵巢CCC的210例患者。干预措施：根据共存的子宫内膜异位症将患者分为两组。进行临床病理特征的比较。采用Kaplan-Meier模型和考克斯回归分析进行生存分析，主要指标：临床病理参数和生存结果。子宫内膜异位症患者比无子宫内膜异位症患者年轻8岁。他们更可能在早期（78.5%）出现原发手术可切除的肿瘤（最佳细胞减灭率为89.9%）和铂敏感性疾病（51.7%）。子宫内膜异位症患者的中位总生存期为115个月，与无子宫内膜异位症患者的63个月相比，增加了52个月。子宫内膜异位症患者的5年生存率为70.2%，而非子宫内膜异位症患者的5年生存率为52.6%。单因素和多因素分析显示，并存的子宫内膜异位症不是生存结局的独立预测因素。结论：卵巢CCC合并子宫内膜异位症患者具有不同的临床病理特征和较好的生存结局。然而，子宫内膜异位症本身并不能提高生存率。(C)2014年，美国生殖医学会（American Society for Reproductive Medicine）
Objective: To analyze and compare the clinicopathological features and prognosis of ovarian clear cell carcinoma (CCC) with or without endometriosis in Chinese patients.Design: Comparative study based on a retrospective review of medical charts.Setting: A general university hospital.Patient(s): Two hundred ten patients diagnosed and treated with ovarian CCC between 2000 and 2012.Intervention(s): Patients were divided into two groups depending on coexisting endometriosis. A comparison of clinicopathological characteristics was performed. The Kaplan-Meier model and Cox regression were employed in survival analysis.Main Outcome Measure(s): Clinicopathological parameters and survival outcomes.Result(s): Of 210 patients, 79 (37.6%) were confirmed to have concurrent endometriosis. Patients with endometriosis were 8 years younger than those without. They were more likely to present at early stage (78.5%) with resectable tumors in primary surgery (with optimal cytoreduction rate at 89.9%) and platinum-sensitive disease (51.7%). Median overall survival for patients with endometriosis was 115 months, an increase of 52 months when compared with 63 months for patients without endometriosis. The 5-year survival rate in patients with endometriosis was 70.2%, while it was 52.6% for those without. Univariate and multivariate analysis showed that coexisting endometriosis was not an independent predictor of survival outcome. Tumor stage and optimal debulking were the independent prognostic factors for both overall survival and progression-free survival.Conclusion(s): Patients with ovarian CCC and coexisting endometriosis had distinct clinicopathological features and better survival outcome. However, endometriosis per se did not confer improved survival. (C) 2014 by American Society for Reproductive Medicine.