Direct ortho-Arylation of ortho-Substituted Benzoic Acids: Overriding Pd-Catalyzed Protodecarboxylation
Direct ortho-Arylation of ortho-Substituted Benzoic Acids: Overriding Pd-Catalyzed Protodecarboxylation
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DOI：
10.1021/ol400065j
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发表时间：
2013-02-15
期刊：
影响因子：
5.2
通讯作者：
Larrosa, Igor
中科院分区：
文献类型：
--
作者：
Arroniz, Carlos;Ironmonger, Alan;Larrosa, Igor
邻位取代的苯甲酸的邻位芳基化是一个具有挑战性的过程，因为反应产物倾向于Pd催化的原脱羧。报道了一种防止位阻苯甲酸脱羧的简便方法。所述方法代表了2-芳基-6-取代苯甲酸的可靠和广泛适用的入口。
ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.