PCBs, DDE, and child development at 18 and 24 months.
PCBs, DDE, and child development at 18 and 24 months.
复制标题
DOI：
10.1016/1047-2797(91)90010-a
复制
发表时间：
1991-08-01
影响因子：
5.6
通讯作者：
Gladen, B C
中科院分区：
文献类型：
--
作者：
Rogan, W J;Gladen, B C
为了确定围产期暴露于“背景”水平的多氯联苯（PCBs）或二氯二苯二氯乙烯（DDE）是否会影响儿童发育，我们对一组2岁以下的儿童进行了随访; 676名儿童在18个月时和670名儿童在24个月时进行了Bayley量表测试。通过对母乳和其他样本的分析，估计了每名儿童从母乳中对这两种化学品的经胎盘和累积暴露。贝利测试是在不知道化学水平的情况下进行的。在18个月和24个月时，经胎盘PCB暴露前5%的儿童在心理量表上的调整分数低4至9分，在24个月时明显如此。通过母乳接触多氯联苯和接触DDE都没有明显的一致影响。我们的结论是，有一个小的延迟，在运动成熟可归因于经胎盘暴露于多氯联苯，仍然是可检测的24个月。没有证据表明，通过母乳接触较大但较晚会产生影响，但随着儿童年龄的增长，影响可能会出现。
To determine whether perinatal exposure to "background" levels of polychlorinated biphenyls (PCBs) or dichlorodiphenyldichloroethene (DDE) affected child development, we followed a cohort of children through the age of 2 years; 676 were tested at 18 months and 670 at 24 months with the Bayley Scales. Transplacental and cumulative exposures from breast milk to both chemicals were estimated for each child from analyses of breast milk and other samples. Bayley testing was done without knowing the chemical levels. At 18 and 24 months, adjusted scores on the psychomotor scales were 4 to 9 points lower among children in the top fifth percentile of transplacental PCB exposure, significantly so at 24 months. There were no consistent effects apparent from exposure to PCBs through breast milk, nor from DDE exposure. We conclude that there is a small delay in motor maturation attributable to transplacental exposure to PCBs that is still detectable at 24 months. There is no evidence of an effect from the larger but later exposure through breast milk, although effects may emerge as the children age.