ER functions are exploited by viruses to support distinct stages of their life cycle.
ER functions are exploited by viruses to support distinct stages of their life cycle.
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DOI：
10.1042/bst20200395
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发表时间：
2020-10-30
影响因子：
3.9
通讯作者：
Tsai B
中科院分区：
文献类型：
--
作者：
Chen YJ;Bagchi P;Tsai B
内质网（ER）具有庞大的膜系统以及由分子伴侣、酶、传感器和离子通道组成的巨大网络，它协调多种细胞功能，包括从蛋白质合成、折叠、分泌和降解到脂质生物合成以及钙稳态。引人注目的是，内质网的一些功能被病毒利用以促进其生命周期。在入侵过程中，病毒必须穿透宿主细胞膜并到达细胞内的某个位置以表达和复制其基因组。这些事件导致新的病毒子代组装并离开宿主细胞，从而引发进一步的感染循环。在这篇综述中，我们重点阐述三种不同的病毒——多瘤病毒、黄病毒和冠状病毒——是如何利用内质网的关键功能来引发感染的。我们预期，阐明这种病毒 - 内质网的相互作用将为对抗病毒引发的疾病提供合理的治疗方法。
The endoplasmic reticulum (ER), with its expansive membranous system and a vast network of chaperones, enzymes, sensors, and ion channels, orchestrates diverse cellular functions, ranging from protein synthesis, folding, secretion, and degradation to lipid biogenesis and calcium homeostasis. Strikingly, some of the functions of the ER are exploited by viruses to promote their life cycles. During entry, viruses must penetrate a host membrane and reach an intracellular destination to express and replicate their genomes. These events lead to the assembly of new viral progenies that exit the host cell, thereby initiating further rounds of infection. In this review, we highlight how three distinct viruses — polyomavirus, flavivirus, and coronavirus — co-opt key functions of the ER to cause infection. We anticipate that illuminating this virus-ER interplay will provide rational therapeutic approaches to combat the virus-induced diseases.