Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen:: a multicentre study in Japan
Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen:: a multicentre study in Japan
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DOI：
10.1007/s00259-003-1430-8
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发表时间：
2004-05-01
影响因子：
9.1
通讯作者：
Senda, M
中科院分区：
文献类型：
--
作者：
Ito, H;Kanno, I;Senda, M
使用氧-15标记的二氧化碳（（CO2）-O-15）或O-15标记的水（（H2O）-O-15），通过正电子发射断层扫描（PET）测量脑血流量（CBF）、脑血容量（CBV）、脑氧提取分数（OEF）和脑氧代谢率（CMRO 2），O-15标记的一氧化碳（（CO）-O-15）和O-15标记的氧（O-15（2））可用于脑血管疾病的诊断和治疗计划。理论上，测量值取决于各种因素，这些因素在PET中心之间可能不同。本研究通过检查中心间和中心内数值变异，探讨了O-15-PET数据库的适用性。11个PET中心参与了这项多中心研究; 7个使用稳态吸入法，1个使用累积吸入法，3个使用（CO2）-O-15（或（H2O）-O-15）和O-15的推注给药（2）。均使用（CO）-O-15测定CBV。受试者包括70名健康志愿者（43名男性和27名女性;平均年龄51.8 ± 15.1岁）。大脑皮质区域的总体平均+/-SD值为：CBF=44.4+/-6.5 ml 100 ml（-1）min（-1）; CBV=3.8+/-0.7 ml 100 ml（-1）; OEF=0.44+/-0.06; CMRO 2 =3.3+/-0.5 ml 100 ml（-1）min（-1）。通过单因素方差分析观察到CBV、OEF和CMRO 2存在显著的中心间变异。然而，CBF、CBV、OEF和CMRO 2的总体个体间差异较小。建立一个由（15）O-PET方法获得的正常脑血流动力学数据库可能是可行的。
Measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) by positron emission tomography (PET) with oxygen-15 labelled carbon dioxide ((CO2)-O-15) or O-15-labelled water ((H2O)-O-15), O-15-labelled carbon monoxide ((CO)-O-15) and O-15-labelled oxygen (O-15(2)) is useful for diagnosis and treatment planning in cases of cerebrovascular disease. The measured values theoretically depend on various factors, which may differ between PET centres. This study explored the applicability of a database of O-15-PET by examining between-centre and within-centre variation in values. Eleven PET centres participated in this multicentre study; seven used the steady-state inhalation method, one used build-up inhalation and three used bolus administration of (CO2)-O-15 (or (H2O)-O-15) and O-15(2). All used (CO)-O-15 for measurement of CBV. Subjects comprised 70 healthy volunteers (43 men and 27 women; mean age 51.8+/-15.1 years). Overall mean+/-SD values for cerebral cortical regions were: CBF=44.4+/-6.5 ml 100 ml(-1) min(-1); CBV=3.8+/-0.7 ml 100 ml(-1); OEF=0.44+/-0.06; CMRO2=3.3+/-0.5 ml 100 ml(-1) min(-1). Significant between-centre variation was observed in CBV, OEF and CMRO2 by one-way analysis of variance. However, the overall inter-individual variation in CBF, CBV, OEF and CMRO2 was acceptably small. Building a database of normal cerebral haemodynamics obtained by the(15)O-PET methods may be practicable.