A prospective comparison of video colonoscopy and CT colonography in asymptomatic patients screened for colorectal cancer
A prospective comparison of video colonoscopy and CT colonography in asymptomatic patients screened for colorectal cancer
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DOI：
10.1055/s-0030-1262457
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发表时间：
2010-08-01
影响因子：
0.6
通讯作者：
Wagner, M.
中科院分区：
文献类型：
--
作者：
Juchems, M.;Roempp, A.;Wagner, M.
背景和目的：本研究的目的是比较低剂量CT结肠成像（CTC）的灵敏度和特异性与光学结肠镜检查（OC）在无症状患者接受这些测试中的筛选程序为colonic cancer.Patients和方法：58例患者（平均年龄62.6岁）。他们接受了低剂量CTC，然后立即进行结肠镜检查。结肠镜检查者不知道CTC结果。结果：共检出150个病变，并经病理证实。136例为息肉样病变，分为增生性息肉（n = 66）或息肉伴上皮内瘤变（n = 70）。在按患者分析中，只有22.4%的患者没有息肉样病变，27.6%的患者至少有一处增生性病变，50.0%的患者至少有一处腺瘤性病变。CTC和OC对所有大小类别腺瘤的敏感性分别为55.7%和92.9%。这种显着的差异（无论是检测个别病变和每例患者的分析）不达到显着性的双侧McNemar test.Conclusions：有一个高患病率的病变与上皮内瘤样病变在这个筛选组。在检测小于10 mm的病变时，OC的敏感性高于CTC。
Background and objective: It was the aim of this study to compare the sensitivity and specificity of low-dose CT colonography (CTC) with that of optical colonoscopy (OC) in asymptomatic patients undergoing these tests in a screening program for colonic cancer.Patients and methods: 58 patients (mean age 62.6 years) were included. They underwent low dose CTC and, immediately afterwards, colonoscopy. The colonoscopists were unaware of the CTC findings. A, second look" was performed if a lesion seen in CTC had been missed in the first colonoscopy.Results: A total of 150 lesions were detected and histologically confirmed. 136 were found to be polypoid lesions, classified as either hyperplastic polyps (n = 66) or polyps with intraepithelial neoplasia (n = 70). In the per-patient analysis only 22.4% of patients had no polypoid lesion, 27.6% had at least one hyperplastic and 50.0% had at least one adenomatous lesion. Sensitivity for adenomas of all size categories was calculated 55.7% for CTC and 92.9% for OC. This marked difference (both for the detection of individual lesions and the per-patient analyses) does not reach significance in the two-sided McNemar test.Conclusions: There was a high prevalence of lesions with intraepithelial neoplasia in this screening group. OC had a higher sensitivity than CTC in the detection of lesions smaller than 10 mm.