The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer
The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer
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DOI：
10.1093/emboj/18.21.6062
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发表时间：
1999-11-01
期刊：
影响因子：
11.4
通讯作者：
Niehrs, C
中科院分区：
文献类型：
--
作者：
de Souza, FSJ;Gawantka, V;Niehrs, C
早期非洲爪蟾原肠胚的前内中胚层是Spemann组织者的一部分，对头部诱导很重要。在这里，我们描述了Xblimp1，它编码的锌指转录抑制表达的前内中胚层。Xblimp1抑制躯干中胚层和诱导前内中胚层的合作方式与泛内胚层基因混合。I.此外，Xblimp1可以与BMP抑制剂脊索蛋白合作诱导异位头部，而显性负性Xblimp1抑制头部形成。头部诱导器cerberus受到Xblimp1的正调控，能够拯救显性负性Xblimp1引起的小头畸形胚胎。我们的研究结果表明，Xblimp1所需的前内中胚层细胞的命运和头部诱导。
The anterior endomesoderm of the early Xenopus gastrula is a part of Spemann's organizer and is important for head induction. Here we describe Xblimp1, which encodes a zinc finger transcriptional repressor expressed in the anterior endomesoderm. Xblimp1 represses trunk mesoderm and induces anterior endomesoderm in a cooperative manner with the pan-endodermal gene Mix. I. Furthermore, Xblimp1 can cooperate with the BMP inhibitor chordin to induce ectopic heads, while a dominant-negative Xblimp1 inhibits head formation. The head inducer cerberus is positively regulated by Xblimp1 and is able to rescue microcephalic embryos caused by dominant-negative Xblimp1. Our results indicate that Xblimp1 is required for anterior endomesodermal cell fate and head induction.