Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs
Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs
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DOI：
10.1073/pnas.0808428106
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发表时间：
2009-02-17
影响因子：
11.1
通讯作者：
Jorntell, Henrik
中科院分区：
文献类型：
--
作者：
Bengtsson, Fredrik;Jorntell, Henrik
处理感觉诱发的突触输入所依据的计算原理只是初步了解。一个关键的缺失因素是对处理神经元的突触输入的激活模式的了解。在这里，我们使用定义明确，可重复的皮肤刺激来描述特定的信号转换，发生在不同的平行苔藓纤维通路和分析其代表性的突触输入小脑颗粒细胞。我们发现，苔藓纤维的输入代码保存在颗粒细胞的突触反应，这表明编码特定的神经支配。计算结果表明，颗粒细胞也可以以分级的方式传递微弱的感觉输入，并保持苔藓纤维的特定活动模式。
The computational principles underlying the processing of sensory-evoked synaptic inputs are understood only rudimentarily. A critical missing factor is knowledge of the activation patterns of the synaptic inputs to the processing neurons. Here we use well-defined, reproducible skin stimulation to describe the specific signal transformations that occur in different parallel mossy fiber pathways and analyze their representation in the synaptic inputs to cerebellar granule cells. We find that mossy fiber input codes are preserved in the synaptic responses of granule cells, suggesting a coding-specific innervation. The computational consequences of this are that it becomes possible for granule cells to also transmit weak sensory inputs in a graded fashion and to preserve the specific activity patterns of the mossy fibers.