A lethal disease model for hantavirus pulmonary syndrome
A lethal disease model for hantavirus pulmonary syndrome
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DOI：
10.1006/viro.2001.1133
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发表时间：
2001-10-10
期刊：
影响因子：
3.7
通讯作者：
Schmaljohn, CS
中科院分区：
文献类型：
--
作者：
Hooper, JW;Larsen, T;Schmaljohn, CS
汉坦病毒与两种人类疾病有关，即肾综合征出血热（HFRS）和汉坦病毒肺综合征（HPS）。由于缺乏实用的动物模型，预防和治疗HFRS和HPS的疫苗和疗法的开发受到阻碍。在这里，我们报告说，安第斯山脉病毒（ANDV），南美汉坦病毒，是高度致命的成年叙利亚仓鼠。仓鼠的疾病特征，包括潜伏期、快速进展的呼吸窘迫症状以及肺水肿和胸腔积液的病理学发现，与人类的HPS非常相似。这是第一份关于导致HPS的汉坦病毒致死性疾病模型的报告。
Hantaviruses are associated with two human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Development of vaccines and therapies to prevent and treat HFRS and HPS have been hampered by the absence of a practical animal model. Here we report that Andes virus (ANDV), a South American hantavirus, is highly lethal in adult Syrian hamsters. The characteristics of the disease in hamsters, including the incubation period, symptoms of rapidly progressing respiratory distress, and pathologic findings of pulmonary edema and pleural effusion, closely resemble HPS in humans. This is the first report of a lethal disease model for hantaviruses that causes HPS.