Effect of hexachlorobiphenyl on vitamin A homeostasis in the rat.
Effect of hexachlorobiphenyl on vitamin A homeostasis in the rat.
复制标题
六氯联苯对大鼠维生素 A 稳态的影响。
DOI：
10.1016/s0304-4165(89)80050-9
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Zile,MH
中科院分区：
文献类型：
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作者：
Bank,PA;Cullum,ME;Jensen,RK;Zile,MH
对长期接受 3,4,5,3',4',5'-六氯联苯 (HCB) 1 mg/kg 饮食治疗的大鼠进行了维生素 A 状态和周转率的检查。 HCB 导致维生素 A 的肝脏耗竭和肾脏积聚，并使血清视黄醇浓度增加 1.7 倍。静脉注射与视黄醇结合蛋白-运甲状腺素蛋白复合物（RBP-TTR复合物）结合的[3H]视黄醇用于研究这些大鼠中视黄醇循环的动态。在 HCB 治疗的大鼠中，与维生素 A 充足的未治疗对照组相比，视黄醇的血浆周转率有所增加。 HCB 导致肝脏总放射性降低 50%，并且除了[3H]视黄醇-RBP-TTR 剂量后 0.5 小时外，肝脏视黄酯库的比活性比对照大鼠更高。 HCB 治疗大鼠的肾脏在视黄酯部分中积累了放射性。与对照大鼠相比，HCB 还导致肾上腺放射性降低 50%。与对照组相比，HCB 治疗大鼠的尿液和粪便中放射性排泄量高出 3 倍。我们的研究结果表明，长期 HCB 喂养会导致血浆维生素 A 质量增加、肝脏和肾脏视黄醇和视黄酯池动态变化以及维生素 A 代谢增加。
Vitamin A status and turnover were examined in rats that had been exposed to chronic dietary treatment of 3,4,5,3′,4′,5′-hexachlorobiphenyl (HCB), 1 mg/kg diet. HCB caused hepatic depletion and renal accumulation of vitamin A, and a 1.7-fold increase in the serum retinol concentration. Intravenously administered [3H]retinol bound to retinol binding protein-transthyretin complex (RBP-TTR complex) was used to study the dynamics of circulatory retinol in these rats. In HCB-treated rats, the plasma turnover rate of retinol was increased compared to vitamin A-adequate untreated controls. HCB caused a 50% reduction of total radioactivity in liver, and, except for 0.5 h after the [3H]retinol-RBP-TTR dose, the specific activity of the hepatic retinyl ester pool was greater compared to control rats. The kidneys of HCB-treated rats accumulated radioactivity in the retinyl ester fraction. HCB also caused a 50% reduction in adrenal radioactivity compared with control rats. Urinary and fecal excretion of radioactivity was 3-fold higher in HCB-treated rats as compared to controls. Our findings demonstrate that chronic HCB feeding results in expansion of plasma vitamin A mass, in changes of liver and kidney retinol and retinyl ester pool dynamics and in an increased metabolism of vitamin A.