Efficacy and safety of stereotactic radiosurgery for pulmonary metastases from osteosarcoma: Experience in 73 patients.
Efficacy and safety of stereotactic radiosurgery for pulmonary metastases from osteosarcoma: Experience in 73 patients.
复制标题
立体定向放射外科治疗骨肉瘤肺转移的疗效和安全性：73 例患者的经验。
DOI：
10.1038/s41598-017-14521-7
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发表时间：
2017-12-12
影响因子：
4.6
通讯作者：
Shen Z
中科院分区：
文献类型：
--
作者：
Yu W;Liu Z;Tang L;Lin F;Yao Y;Shen Z
骨肉瘤肺转移通常用切除和/或化疗治疗。我们假设，立体定向放射外科（SRS）可以替代外科手术，可以实现高的局部控制率和有限的毒性。2005年1月至2013年12月，分析了73例在辅助化疗或随访期间发生肺转移的患者。33例患者采用体部伽玛刀系统进行立体定向放射外科治疗。以5戈伊/次向覆盖计划靶体积的50%等剂量线输送50戈伊的总剂量，而以7戈伊/次向总靶体积输送70戈伊的总剂量。其余40例均行手术切除。SRS组4年无进展生存率、4年生存率、复发后中位无进展生存期（PRPFS）和复发后总生存期（PROS）与手术组相似。患者对伽玛刀治疗耐受良好。我们的研究表明SRS耐受性良好，局部控制良好，并发症少。SRS应被视为骨肉瘤肺转移患者的一种潜在选择，特别是那些医学上无法手术，拒绝手术的患者。
Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary metastasis during period of adjuvant chemotherapy or follow-up were analyzed. 33 patients were treated by stereotactic radiosurgery using the body gamma-knife system. A total dose of 50 Gy was delivered at 5 Gy/fraction to the 50% isodose line covering the planning target volume, whereas a total dose of 70 Gy was delivered at 7 Gy/fraction to the gross target volume. The other 40 patients were treated by surgical resection. Four-year progression-free survival rate, four-year survival rate, median time of PRPFS (post-relapse progress-free survival) and PROS (post-relapse overall survival) in SRS group were parallel to that in surgical group. Patients tolerated gamma knife radiosurgery well. Our study demonstrates that SRS is well-tolerated with excellent local control and less complications. SRS should be considered as a potential option in patients with pulmonary metastases from osteosarcoma, especially in those who are medically inoperable, refuse surgery.
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DOI：
10.1053/j.semtcvs.2008.12.001
发表时间：
2008-12-01
影响因子：
2.5
作者：
Christie, Neil A.;Pennathur, Arjun;Luketich, James D.
通讯作者：
Luketich, James D.
影响因子：
6.2
作者：
Briccoli, A;Rocca, M;Mercuri, M
通讯作者：
Mercuri, M
影响因子：
45.3
作者：
MEYERS, PA;HELLER, G;LAQUAGLIA, M
通讯作者：
LAQUAGLIA, M
影响因子：
45.3
作者：
Bielack, Stefan S.;Kempf-Bielack, Beate;Juergens, Heribert
通讯作者：
Juergens, Heribert
影响因子：
4.6
作者：
Pennathur, Arjun;Luketich, James D.;Christie, Neil A.
通讯作者：
Christie, Neil A.