Synthesis and characterization of an electroactive surface that releases gamma-aminobutyric acid (GABA).
Synthesis and characterization of an electroactive surface that releases gamma-aminobutyric acid (GABA).
复制标题
释放γ-氨基丁酸（GABA）的电活性表面的合成和表征。
DOI：
10.1016/j.jcis.2005.08.029
复制
发表时间：
2006
影响因子：
9.9
通讯作者：
Leckband,DeborahE
中科院分区：
文献类型：
--
作者：
Yan,Chun;Matsuda,Wakana;Pepperberg,DavidR;Zimmerman,StevenC;Leckband,DeborahE
We report the synthesis and characterization of a new electroactive surface capable of releasing the neurotransmitter γ-aminobutyric acid (GABA) upon reduction. The GABA was anchored to an alkanethiol via electrochemically active quinone (abbreviation, TM-GABA). The quinone unit, upon reduction to the hydroquinone, cyclizes to release GABA into solution. The half-life is 99 s. The self-assembled monolayer (SAM) of TM-GABA on gold was prepared and characterized with several surface sensitive techniques. X-ray photoelectron spectroscopy (XPS) explored the SAM formation of TM-GABA on Au surfaces. Cyclic voltammograms showed the ability to electrochemically control the quinone unit at the distal end of the chain. GABA was selectively released upon electrochemical reduction at a potential of −700 mV. The functional GABA terminal group was detected by surface plasmon resonance measurements of anti-GABA antibody binding.
DOI：
10.1084/jem.141.2.427
发表时间：
1975-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brem H;Folkman J
通讯作者：
Folkman J