Menstrual phase effects on smoking relapse
Menstrual phase effects on smoking relapse
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DOI：
10.1111/j.1360-0443.2008.02146.x
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发表时间：
2008-05-01
期刊：
影响因子：
6
通讯作者：
Hatsukami, Dorothy
中科院分区：
文献类型：
--
作者：
Allen, Sharon S.;Bade, Tracy;Hatsukami, Dorothy
目的研究月经期是否影响试图戒烟的女性的复发。设计：一项意向性治疗的随机戒烟试验，女性被分配在卵泡期（F）或黄体期（L）戒烟，并随访长达26周。根据复发天数和复发期评估他们的复发情况，以确定在F期开始尝试戒烟的患者是否比在L期开始尝试戒烟的患者更成功。明尼苏达大学烟草使用研究中心，明尼阿波利斯，明尼苏达州。参加者：202名妇女。测量从连续和长期戒断到复发的潜伏期、点患病率、复发阶段、戒烟后前3天和5天内的首次脱落、受试者完成率和成瘾学（即戒断和渴望）。结果：F组从连续禁欲到复发和从长期禁欲到复发的平均天数分别为13.9和20.6天，L组分别为21.5和39.2天。使用14天的点患病率分析，F组84%复发，L组65%复发[卡方（2）= 10.024，P = 0.002;比值比（OR）= 2.871，95%置信区间（CI），1.474-5.590]。30天时，F组86%复发，L组66%复发（卡方2 = 11.076，P = 0.001; OR = 3.178，95%CI，1.594-6.334）。结论在F期尝试戒烟的女性比在L期尝试戒烟的女性有更不利的结局。这可能与卵巢激素有关，卵巢激素可能在女性戒烟中发挥作用。
Aims To examine if menstrual phase affects relapse in women attempting to quit smoking. Design An intent-to-treat randomized smoking cessation trial where women were assigned to quit smoking in either the follicular (F) or luteal (L) menstrual phase and were followed for up to 26 weeks. They were assessed for relapse by days to relapse and relapse phase to determine if those who begin a quit attempt during the F phase were more successful than those who begin during the L phase. Setting Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota. Participants A total of 202 women. Measurements Latency to relapse from continuous and prolonged abstinence, point prevalence, phase of relapse, first slip within the first 3 and 5 days post-quit date, subject completion rates and symptomatology (i.e. withdrawal and craving). Findings The mean days to relapse from continuous abstinence and relapse from prolonged abstinence for the F group were 13.9 and 20.6 days, respectively, and 21.5 and 39.2 days, respectively, for the L group. Using point prevalence analysis at 14 days, 84% of the F group had relapsed compared with 65% of the L group [chi(2) = 10.024, P = 0.002; odds ratio (OR) = 2.871, 95% confidence interval (CI), 1.474-5.590]. At 30 days, 86% of the F group relapsed, compared with 66% of the L group (chi(2) = 11.076, P = 0.001; OR = 3.178, 95% CI, 1.594-6.334). Conclusion Women attempting to quit smoking in the F phase had less favorable outcomes than those attempting to quit in the L phase. This could relate to ovarian hormones, which may play a role in smoking cessation for women.