Efficacy of pyrethroid-treated nets against malaria vectors and nuisance-biting mosquitoes in Tanzania in areas with long-term insecticide-treated net use
Efficacy of pyrethroid-treated nets against malaria vectors and nuisance-biting mosquitoes in Tanzania in areas with long-term insecticide-treated net use
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DOI：
10.1111/j.1365-3156.2007.01883.x
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Drakeley, Chris
中科院分区：
文献类型：
--
作者：
Kulkarni, Manisha A.;Malima, Robert;Drakeley, Chris
目的测定坦桑尼亚疟疾病媒和叮咬蚊虫对拟除虫菊酯的敏感性，并测试目前用于蚊帐处理的杀虫剂制剂的生物学效力。一个. funestus Giles s.l.和致倦库蚊说，收集在坦桑尼亚的三个国家调查和两个杀虫剂处理的蚊帐（ITN）的研究。击倒效应和死亡率在标准的世卫组织敏感性试验和球框生物功效试验中测量。从1999年到2004年的测试结果进行了比较，以确定耐药性发展的趋势。和一个.富内斯图斯公司在1999年和2004年的WHO检测中，致倦库蚊对氯菊酯（87-100%）和溴氰菊酯（100%）高度敏感，而致倦库蚊对这些拟除虫菊酯的敏感性要低得多（分别为7-100%和0-84%）。经拟除虫菊酯处理的蚊帐对安氏按蚊的效力同样高。冈比亚有限公司和一个.富内斯图斯公司（范围82-100%），而对Cx. quinquefasciatus显著较低（范围2-100%）。没有迹象表明，在人口的耐药性的发展。冈比亚公司或.富内斯图斯公司其中，驱虫蚊帐已被广泛使用;然而，滋扰叮咬Cx的易感性。1999 ~ 2004年，致倦库蚊在部分地区出现下降趋势。结论坦桑尼亚疟疾媒介对拟除虫菊酯的持续敏感性对使用驱虫蚊帐成功控制疟疾是令人鼓舞的。持续监测对于确保及早发现抗药性至关重要，特别是在农业或公共卫生大量使用杀虫剂的地区，因为这些地区很可能产生抗药性。叮咬害虫的库蚊对驱虫蚊帐的敏感性普遍较低，这引起了人们对蚊帐使用者接受程度的关注。
OBJECTIVE To measure pyrethroid susceptibility in populations of malaria vectors and nuisance-biting mosquitoes in Tanzania and to test the biological efficacy of current insecticide formulations used for net treatment.METHODS Anopheles gambiae Giles s.l., An. funestus Giles s.l. and Culex quinquefasciatus Say were collected during three national surveys and two insecticide-treated net (ITN) studies in Tanzania. Knockdown effect and mortality were measured in standard WHO susceptibility tests and ball-frame bio-efficacy tests. Test results from 1999 to 2004 were compared to determine trends in resistance development.RESULTS Anopheles gambiae s.l. and An. funestus s.l. were highly susceptible to permethrin (range 87-100%) and deltamethrin (consistently 100%) in WHO tests in 1999 and 2004, while Culex quinquefasciatus susceptibility to these pyrethroids was much lower (range 7-100% and 0-84% respectively). Efficacy of pyrethroid-treated nets was similarly high against An. gambiae s.l. and An. funestus s.l. (range 82-100%) while efficacy against Cx. quinquefasciatus was considerably lower (range 2-100%). There was no indication of development of resistance in populations of An. gambiae s.l. or An. funestus s.l. where ITNs have been extensively used; however, susceptibility of nuisance-biting Cx. quinquefasciatus mosquitoes declined in some areas between 1999 and 2004.CONCLUSION The sustained pyrethroid susceptibility of malaria vectors in Tanzania is encouraging for successful malaria control with ITNs. Continued monitoring is essential to ensure early resistance detection, particularly in areas with heavy agricultural or public health use of insecticides where resistance is likely to develop. Widespread low susceptibility of nuisance-biting Culex mosquitoes to ITNs raises concern for user acceptance of nets.