A randomized controlled trial of cognitive remediation and d-cycloserine for individuals with bipolar disorder.
A randomized controlled trial of cognitive remediation and d-cycloserine for individuals with bipolar disorder.
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DOI：
10.1186/s40359-014-0041-4
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发表时间：
2014
期刊：
影响因子：
3.6
通讯作者：
Moreno F
中科院分区：
文献类型：
--
作者：
Breitborde NJ;Dawson SC;Woolverton C;Dawley D;Bell EK;Norman K;Polsinelli A;Bernstein B;Mirsky P;Pletkova C;Grucci F 3rd;Montoya C;Nanadiego B;Sarabi E;DePalma M;Moreno F
认知矫正（CR）在解决严重精神疾病带来的认知缺陷方面显示出巨大的前景。然而，这种干预似乎并不能完全改善伴随这些疾病而来的认知缺陷。 D-环丝氨酸 (DCS) 是一种 NMDA 受体部分激动剂，已被证明可以增强基于学习的心理社会干预对精神疾病的治疗效果。因此，本研究的目的是检验认知矫正和 d-环丝氨酸相结合在治疗双相情感障碍患者认知缺陷中的效用。大约四十名双相情感障碍患者将被招募参加这项研究。参与者将被随机分配到两个研究组之一：CR + DCS 或 CR + 安慰剂。这项研究的主要结果是认知功能的变化。我们还将检查一些次要结果，包括认知功能、社会功能和症状的变化率。认知缺陷是双相情感障碍患者功能恢复的限速因素。不幸的是，针对这些缺陷的治疗选择是有限的。拟议研究的结果可能揭示一种有价值的干预策略（即 CR 与并发 DCS），以改善双相情感障碍患者的认知功能。最终，这种治疗策略可能有助于解决严重精神疾病中普遍存在的认知缺陷。 ClinicalTrials.gov NCT01934972。
Cognitive remediation (CR) has shown significant promise in addressing the cognitive deficits that accompany serious mental illness. However, this intervention does not appear to completely ameliorate the cognitive deficits that accompany these illnesses. D-cycloserine (DCS), an NMDA receptor partial agonist, has been shown to enhance the therapeutic benefits of learning-based psychosocial interventions for psychiatric disorders. Thus, the goal of this study is to examine the utility of combining cognitive remediation and d-cycloserine in the treatment of cognitive deficits among individuals with bipolar disorder. Approximately forty individuals with bipolar disorder will be recruited to participate in this study. Participants will be randomized to one of two study arms: CR + DCS or CR + placebo. The primary outcome for this study is change in cognitive functioning. We will also examine several secondary outcomes, including the rate of change of cognitive functioning, social functioning, and symptomatology. Cognitive deficits are a rate-limiting factor in functional recovery among individuals with bipolar disorder. Unfortunately, treatment options for these deficits are limited. The results of the proposed study may reveal a valuable intervention strategy (i.e., CR with concurrent DCS) to improve cognitive functioning among individuals with bipolar disorder. Ultimately, this treatment strategy may prove useful in addressing the cognitive deficits that are ubiquitous across serious mental illnesses. ClinicalTrials.gov NCT01934972.