Intrathecal immunoglobulin production in patients with systemic lupus erythematosus with neuropsychiatric manifestations
Intrathecal immunoglobulin production in patients with systemic lupus erythematosus with neuropsychiatric manifestations
复制标题
具有神经精神表现的系统性红斑狼疮患者鞘内免疫球蛋白的产生
DOI：
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发表时间：
2007
影响因子：
27.4
通讯作者：
C. Sing Lau
中科院分区：
文献类型：
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作者：
Mo Yin Mok;E. Chan;Woon Sing Wong;C. Sing Lau
据报道，30-60%的系统性红斑狼疮（SLE）患者有神经精神症状，脑脊液（CSF）中IgG合成可变。1在这项研究中，我们试图检查鞘内IgG合成，定性测量IgG指数，2使用公式计算
(IgG CSF/IgG血清）/（白蛋白CSF/白蛋白血清），
并通过等电聚焦（IEF）3以寡克隆带（OCB）的形式定量检测具有各种神经系统表现的SLE患者，并确定用于检测这些病理性IgG的IgG指数的截止值。
使用关键词“SLE”或“狼疮”从2902个样本的数据库中检索CSF结果。仅分析了每例患者每次神经系统发作治疗前采集的第一份CSF样本。样品来自...
Neuropsychiatric manifestations have been reported in 30–60% of patients with systemic lupus erythematosus (SLE), with variable IgG synthesis in cerebrospinal fluid (CSF).1 In this study, we sought to examine intrathecal IgG synthesis measured qualitatively as the IgG index,2 calculated using the formula
(IgG CSF/IgG serum)/(albumin CSF/albumin serum),
and quantitatively as oligoclonal bands (OCBs) by isoelectric focusing (IEF)3 in patients with SLE with various neurological presentations, and to determine the cut-off of the IgG index for the detection of these pathological IgG.
CSF results were retrieved from a database of 2902 samples using the keywords “SLE” or “lupus”. Only the first CSF sample taken before treatment for each neurological episode in each patient was analysed. Samples from …