Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga.
Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga.
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DOI：
10.4103/psychiatry.indianjpsychiatry_154_17
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发表时间：
2018-01
影响因子：
3.1
通讯作者：
Nanjundaiah GB
中科院分区：
文献类型：
--
作者：
Halappa NG;Thirthalli J;Varambally S;Rao M;Christopher R;Nanjundaiah GB
认知障碍在重度抑郁症患者中是众所周知的。本研究考察了瑜伽疗法联合或不联合抗抑郁药以及单独使用抗抑郁药对抑郁症患者某些神经心理功能的影响。神经心理测试成绩变化与血清脑源性神经营养因子（BDNF）水平的相关性也进行了探讨。Antidepressant-naïve/无抗抑郁门诊抑郁症患者接受单独抗抑郁药物治疗（n = 23）或瑜伽治疗（n = 26）或不接受抗抑郁药物治疗（n = 16）。采用汉密尔顿抑郁评定量表对抑郁症进行评估。神经心理测试包括数字跨距向前和向后、雷伊听觉语言学习测试和轨迹制造测试（TMT-A和B）。这些测试分别在患者治疗前和治疗后3个月进行，并在健康对照受试者中进行一次（n = 19）。基线差异分析采用独立样本t检验、卡方检验和单因素方差分析。采用配对t检验分析从基线到随访的变化。Pearson’s correlation用于探究两个变量之间变化的关联。患者在大多数神经心理测试中表现不佳。3个月后，有了显著的改善——在大多数测试中，患者的表现与健康对照组相当。单独瑜伽组BDNF水平升高与TMT“A”持续时间改善呈显著负相关（r = - 0.647; P = 0.009）。综上所述，瑜伽疗法，单独或与药物结合，与改善抑郁症患者的神经心理功能和神经可塑性作用有关。
Impairment in cognition is well-known in patients with major depressive disorder. This study examined the effect of yoga therapy with or without antidepressants and antidepressants alone on certain neuropsychological functions in patients with depression. Correlation between changes in neuropsychological test performance and serum brain-derived neurotrophic factor (BDNF) levels was also explored. Antidepressant-naïve/antidepressant-free outpatients with depression received antidepressant medication alone (n = 23) or yoga therapy with (n = 26) or without (n = 16) antidepressants. Depression was assessed using the Hamilton Depression Rating Scale. Neuropsychological tests included digit-span forward and backward, Rey Auditory Verbal Learning Test, and Trail Making Tests (TMT-A and B). These tests were administered before and 3 months after the treatment in patients, and once in healthy comparison subjects (n = 19). Baseline differences were analyzed using independent sample t-test, Chi-square, and one-way ANOVA. Paired t-test was used to analyze the change from baseline to follow-up. Pearson's correlation was used to explore the association of change between 2 variables. Patients had impaired performance on most neuropsychological tests. After 3 months, there was significant improvement – patients’ performance was comparable to that of healthy controls on majority of the tests. Significant inverse correlation was observed between increase in BDNF levels and improvement in TMT “A” duration in Yoga-alone group (r = −0.647; P = 0.009). To conclude that, Yoga therapy, alone or in combination with medications, is associated with improved neuropsychological functions and neuroplastic effects in patients with depression.