Antimicrobial peptide microbicides targeting HIV
Antimicrobial peptide microbicides targeting HIV
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DOI：
10.2174/0929866053406101
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发表时间：
2005-01-01
影响因子：
1.6
通讯作者：
Cole, AM
中科院分区：
文献类型：
--
作者：
Cole, AM
阳离子抗菌肽和蛋白质是人类和其他脊椎动物中先天免疫臂的最早分子效应物之一。这篇综述，灵感来自最近强调的局部预防性性传播感染的发展，介绍了抗菌肽和蛋白质的背景下，杀微生物剂的设计和开发。特别强调的是防御素肽家族。
Cationic antimicrobial peptides and proteins are among the earliest molecular effectors of the innate arm of immunity in humans and other vertebrates. This review, inspired by recent emphasis on the development of topical preventatives for sexually transmitted infections, describes antimicrobial peptides and proteins in the context of microbicide design and development. Particular emphasis is placed on the defensin family of peptides.