Contrast-Enhanced Ultrasound Imaging of the Vasa Vasorum
Contrast-Enhanced Ultrasound Imaging of the Vasa Vasorum
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DOI：
10.1016/j.jcmg.2010.02.007
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发表时间：
2010-07-01
影响因子：
14
通讯作者：
Feinstein, Steven B.
中科院分区：
文献类型：
--
作者：
Staub, Daniel;Schinkel, Arend F. L.;Feinstein, Steven B.
外膜滋养管（VV）的增殖与早期动脉粥样硬化斑块的发展和脆弱性有着内在的联系。最近，动脉 VV 和斑块内新生血管的直接可视化已成为早期检测动脉粥样硬化疾病的新替代标志物。本临床综述重点关注超声造影 (CEUS) 作为一种无创应用，用于识别和量化颈动脉和冠状动脉 VV 以及斑块内新生血管。这些新方法可能会影响临床医生识别患有早发心血管疾病的高危人群的能力。一旦经过临床验证，CEUS 的使用可能会提供一种无创监测治疗干预的方法。未来，CEUS 的治疗用途可能包括使用微泡作为药物和基因递送系统的载体的超声引导、定点治疗。诊断和治疗的组合应用为临床医生提供了独特的机会，对患有易损病变的个体进行成像和指导治疗。 (J Am Coll Cardiol Img 2010;3:761-71) (c) 2010 年，美国心脏病学会基金会
Proliferation of the adventitial vasa vasorum (VV) is inherently linked with early atherosclerotic plaque development and vulnerability. Recently, direct visualization of arterial VV and intraplaque neovascularization has emerged as a new surrogate marker for the early detection of atherosclerotic disease. This clinical review focuses on contrast-enhanced ultrasound (CEUS) as a noninvasive application for identifying and quantifying carotid and coronary artery VV and intraplaque neovascularization. These novel approaches could potentially impact the clinician's ability to identify individuals with premature cardiovascular disease who are at high risk. Once clinically validated, the uses of CEUS may provide a method to noninvasively monitor therapeutic interventions. In the future, the therapeutic use of CEUS may include ultrasound-directed, site-specific therapies using microbubbles as vehicles for drug and gene delivery systems. The combined applications for diagnosis and therapy provide unique opportunities for clinicians to image and direct therapy for individuals with vulnerable lesions. (J Am Coll Cardiol Img 2010;3:761-71) (c) 2010 by the American College of Cardiology Foundation