Porphyrin and phthalocyanine antiscrapie compounds
Porphyrin and phthalocyanine antiscrapie compounds
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DOI：
10.1126/science.287.5457.1503
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发表时间：
2000-02-25
期刊：
影响因子：
56.9
通讯作者：
Caughey, WS
中科院分区：
文献类型：
--
作者：
Priola, SA;Raines, A;Caughey, WS
传染性海绵状脑病（TSE）是一种致命的神经退行性疾病，目前尚无有效的治疗方法。牛 TSE 跨越物种障碍并感染人类的可能性强调了识别抗 TSE 药物的迫切需要。某些环状四吡咯（卟啉和酞菁）最近被证明可以抑制体外 PrP-res 的形成，PrP-res 是一种对 TSE 发病机制至关重要的蛋白酶抗性蛋白。我们现在报道，用三种此类化合物治疗受 TSE 感染的动物，可使存活时间从 50% 延长至 300%。结构不同的四吡咯对 TSE 疾病的显着抑制作用使这些化合物成为抗 TSE 药物。
The transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases for which no effective treatments are available. The Likelihood that a bovine form of TSE has crossed species barriers and infected humans underscores the urgent need to identify anti-TSE drugs. Certain cyclic tetrapyrroles (porphyrins and phthalocyanines) have recently been shown to inhibit the in vitro formation of PrP-res, a protease-resistant protein critical for TSE pathogenesis. We now report that treatment of TSE-infected animals with three such compounds increased survival time from 50 to 300%. The significant inhibition of TSE disease by structurally dissimilar tetrapyrroles identifies these compounds as anti-TSE drugs.