Thioredoxin reductase and its inhibitors.
Thioredoxin reductase and its inhibitors.
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DOI：
10.2174/1389203715666140530091910
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发表时间：
2014
影响因子：
2.8
通讯作者：
Bellelli A
中科院分区：
文献类型：
--
作者：
Saccoccia F;Angelucci F;Boumis G;Carotti D;Desiato G;Miele AE;Bellelli A
硫氧还蛋白在广泛的生理过程中起着至关重要的作用，从核苷酸还原到脱氧核苷，再到对外来生物、氧化剂和自由基的解毒。硫氧还蛋白的氧化还原功能严重依赖于硫氧还蛋白NADPH还原酶（TrxR）。鉴于其间接参与上述生理/病理过程，抑制TrxR是一个重要的临床目标。一般来说，TrxR抑制剂与靶酶的亲和力和结合机制尚不清楚，文献中充斥着相互矛盾的结果。因此，考虑到TrxR抑制剂的关键利益，需要对已发表的结果以及实验程序进行相关分析。我们回顾了TrxR抑制剂和相关的风味还原酶，以及TrxR可逆、竞争性、非竞争性和非竞争性抑制的经典治疗方法，在某些情况下，我们能够调和过度简化的数据分析产生的矛盾结果。
Thioredoxin plays a crucial role in a wide number of physiological processes, which span from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics, oxidants and radicals. The redox function of Thioredoxin is critically dependent on the enzyme Thioredoxin NADPH Reductase (TrxR). In view of its indirect involvement in the above mentioned physio/pathological processes, inhibition of TrxR is an important clinical goal. As a general rule, the affinities and mechanisms of binding of TrxR inhibitors to the target enzyme are known with scarce precision and conflicting results abound in the literature. A relevant analysis of published results as well as the experimental procedures is therefore needed, also in view of the critical interest of TrxR inhibitors. We review the inhibitors of TrxR and related flavoreductases and the classical treatment of reversible, competitive, non competitive and uncompetitive inhibition with respect to TrxR, and in some cases we are able to reconcile contradictory results generated by oversimplified data analysis.
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影响因子：
2.7
作者：
Andricopulo, AD;Akoachere, MB;Becker, K
通讯作者：
Becker, K
影响因子：
7.4
作者：
Arnér, ESJ;Nakamura, H;Spyrou, G
通讯作者：
Spyrou, G
DOI：
10.1046/j.1432-1033.2003.03812.x
发表时间：
2003-11-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Bauer, H;Gromer, S;Müller, HM
通讯作者：
Müller, HM
DOI：
10.1038/nsb0498-267
发表时间：
1998-04-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
--
作者：
Becker, K;Savvides, SN;Karplus, PA
通讯作者：
Karplus, PA
DOI：
10.1111/j.1432-1033.1995.472_b.x
发表时间：
1995-12-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
BECKER, K;GUI, M;SCHIRMER, RH
通讯作者：
SCHIRMER, RH