beta-Carbolinium cations, endogenous MPPplus analogs, in the lumbar cerebrospinal fluid of patients with Parkinson's disease
beta-Carbolinium cations, endogenous MPPplus analogs, in the lumbar cerebrospinal fluid of patients with Parkinson's disease
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帕金森病患者腰部脑脊液中的 β-Carbolinium 阳离子（内源性 MPPplus 类似物）
DOI：
10.1212/wnl.45.12.2240
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发表时间：
1995
期刊：
影响因子：
9.9
通讯作者：
K. Kimura
中科院分区：
文献类型：
--
作者：
K. Matsubara;Shotai Kobayashi;Y. Kobayashi;K. Yamashita;H. Koide;M. Hatta;K. Iwamoto;O. Tanaka;K. Kimura
我们测量了22例特发性帕金森病（PD）患者和11例无帕金森症状的年龄匹配对照者腰椎脑脊液中β -碳离子（BCplus s）， n -甲基-4-苯基吡啶离子（MPPplus）的内源性类似物。在BCplus s中，2,9-二甲基去硝铵阳离子（2,9- me2 NHplus）是最有效的神经毒物，反映了MPPplus在线粒体毒性中的作用，在12例PD患者中存在，而在对照组中没有。虽然几乎所有受试者中都存在2-单甲基化β -碳离子（2-MeBCplus s），但PD患者的水平略高于对照组，但差异并不显著。PD患者总BCplus含量，即2- mebcplus和2,9- me2 NHplus水平的总和显著高于对照组。2- mebcplus含量随着PD的进展而显著增加，但2,9- me2nhplus含量随着疾病的加重而下降，尽管其水平变化范围很广。本研究结果有力地支持了“生物活性”BCplus s，特别是2,9- me2 NHplus s可能是PD的内源性致病因素的假设。神经学1995;45: 2240 - 2245
We measured beta-carbolinium cations (BCplus s), endogenous analogs of the N-methyl-4-phenylpyridinium ion (MPPplus), in the lumbar CSF of 22 patients with idiopathic Parkinson's disease (PD) and 11 age-matched controls without any symptoms of parkinsonism. Among the BCplus s, 2,9-dimethylnorharmanium cation (2,9-Me2 NHplus), the most potent neurotoxicant that mirrors MPPplus in mitochondria toxicity, was present in 12 patients with PD but not in controls. Although the 2-monomethylated beta-carbolinium cations (2-MeBCplus s), which were present in almost all subjects, registered a slightly higher level in PD patients than in controls, the difference was not significant. The total BCplus content, sum of 2-MeBCplus and 2,9-Me2 NHplus levels, was significantly higher in PD patients than in controls. The 2-MeBCplus contents significantly increased with the progression of the PD, but 2,9-ME2 NHplus decreased as the disease exacerbated, although levels varied within a wide range. The present results strongly support the hypothesis that ``bioactivated'' BCplus s, especially 2,9-Me2 NHplus s, may be the endogenous causative factors underlying PD. NEUROLOGY 1995;45: 2240-2245
DOI：
10.1016/0006-291x(85)91071-x
发表时间：
1985-01-01
影响因子：
3.1
作者：
CHIBA, K;TREVOR, AJ;CASTAGNOLI, N
通讯作者：
CASTAGNOLI, N
影响因子：
6.1
作者：
ARORA, PK;RIACHI, NJ;SAYRE, LM
通讯作者：
SAYRE, LM
DOI：
10.1073/pnas.82.7.2173
发表时间：
1985-01-01
影响因子：
11.1
作者：
JAVITCH, JA;DAMATO, RJ;SNYDER, SH
通讯作者：
SNYDER, SH