Thematic series on the pathobiology of vascular calcification: an introduction.
Thematic series on the pathobiology of vascular calcification: an introduction.
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DOI：
10.1161/circresaha.110.234419
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发表时间：
2011-05-27
影响因子：
20.1
通讯作者：
Demer LL
中科院分区：
文献类型：
--
作者：
Towler DA;Demer LL
血管钙化日益困扰着我们老龄化、代谢障碍的人群。曾经被认为只是死亡和死亡细胞的被动过程，来自世界各地多个实验室的数据已经汇聚到一起，证明血管钙化是一种高度受监管的生物矿化形式。这一专题综述系列的目的是强调关于血管矿物质新陈代谢方面的生物“玩家和游戏规则”的已知情况。有了这一认识，我们希望能够设计出新的治疗策略来预防和治疗血管钙积聚，从而使我们患有动脉硬化性瓣膜和血管疾病的患者受益。
Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once considered only a passive process of dead and dying cells, data from multiple laboratories worldwide have converged to demonstrate that vascular calcification is a highly regulated form of biomineralization. The goal of this thematic review series is to highlight what is known concerning the biological “players and game rules” with respect to vascular mineral metabolism. Armed with this understanding, it is hoped that novel therapeutic strategies can be crafted to prevent and treat vascular calcium accrual – to the benefit of our patients afflicted with arteriosclerotic valvular and vascular diseases.