Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans.
Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans.
复制标题
人体跑步后血浆 β-内啡肽/β-促脂激素免疫反应性增加。
DOI：
10.1152/jappl.1982.52.5.1245
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
W. Morgan
中科院分区：
文献类型：
--
作者：
P. Farrell;W. Gates;M. Maksud;W. Morgan
对6名训练有素的耐力运动员进行了研究，以确定次极量跑步机运动是否会导致血浆β-内啡肽/β-促脂素（Bh-Ep/Bh-LPH）免疫反应性水平升高。用放射免疫法测定了6名有经验的跑步者在自选配速、60%和80%VO2 max跑台30 min前后血浆中Bh-Ep/Bh-LPH的免疫反应性，并设对照组。所有试验均随机进行，并在一天中的同一时间（0600- 1500 h）对给定受试者进行。运动前Bh-Ep/Bh-LPH值平均在10至20 pg/ml之间，每次跑步后增加2至5倍。只有在60%运行后，当Bh-Ep/Bh-LPH增加至平均58.3 pg/ml时，增加才具有统计学显著性（P <0.05）。注意到Bh-Ep/Bh-LPH对跑步的反应存在较大的个体差异。情绪状态和知觉数据也被收集，并且与Bh-Ep/Bh-LPH没有明显的关系。这些数据表明，跑步机运行的压力作为刺激更大的Bh-Ep/Bh-LPH分泌，减少其降解，或这些的组合，这导致静脉血中这些配体的水平增加。这些血浆水平升高的生理意义尚不清楚。
Six well-trained endurance athletes were studied to determine if submaximal treadmill exercise results in increased plasma levels of beta-endorphin/beta-lipotropin (Bh-Ep/Bh-LPH) immunoreactivity. Bh-Ep/Bh-LPH immunoreactivity was measured by radio immunoassay in plasma from six experienced runners before and after 30-min treadmill runs at a self-selected pace, 60 and 80% VO2 max, and a control experiment of 30 min rest. All tests were randomized and occurred during the same time of day for a given subject (0600--1500 h). Preexercise Bh-Ep/Bh-LPH values averaged between 10 and 20 pg/ml and increased two- to fivefold after each run. The increase was statistically significant (P less than 0.05) only after the 60% run when Bh-Ep/Bh-LPH increased to a mean of 58.3 pg/ml. A large individual variation in the Bh-Ep/Bh-LPH response to running was noted. Mood state and perceptual data were also collected, and no significant relationship with Bh-Ep/Bh-LPH was evident. These data suggest that the stress of treadmill running acts as a stimulus to greater Bh-Ep/Bh-LPH secretion, a reduction in its degradation, or a combination of these, which leads to increased levels of these ligands in venous blood. The physiological significance of these increased plasma levels is not clear.