Analysis of Recombination and Chromosome Structure during Yeast Meiosis.
Analysis of Recombination and Chromosome Structure during Yeast Meiosis.
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酵母减数分裂过程中的重组和染色体结构分析。
DOI：
10.1101/pdb.top077636
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发表时间：
2015
影响因子：
--
通讯作者：
Cha,RitaS
中科院分区：
文献类型：
--
作者：
Börner,GValentin;Cha,RitaS
减数分裂是一种二倍体特异性分化程序，包括一轮基因组复制，随后是两轮染色体分离。这些事件导致遗传补体减半，这是形成单倍体生殖细胞（即酵母孢子和动植物配子）的必要条件。在第一次减数分裂中，同源的母本和父本染色体配对并分离，而姐妹染色单体在着丝粒处保持连接并在第二次减数分裂中分离。在大多数生物体中，精确的同源分离需要交叉，这是减数分裂重组的产物。在过去的二十年中，对酵母减数分裂的研究为减数分裂的进化保守机制提供了宝贵的见解。
Meiosis is a diploid-specific differentiation program that consists of a single round of genome duplication followed by two rounds of chromosome segregation. These events result in halving of the genetic complement, which is a requirement for formation of haploid reproductive cells (ie, spores in yeast and gametes in animals and plants). During meiosis I, homologous maternal and paternal chromosomes (homologs) pair and separate, whereas sister chromatids remain connected at the centromeres and separate during the second meiotic division. In most organisms, accurate homolog disjunction requires crossovers, which are formed as products of meiotic recombination. For the past two decades, studies of yeast meiosis have provided invaluable insights into evolutionarily conserved mechanisms of meiosis.