Discriminating Down Syndrome and Fragile X syndrome based on language ability.
Discriminating Down Syndrome and Fragile X syndrome based on language ability.
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DOI：
10.1017/s0305000912000207
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发表时间：
2013-01
影响因子：
2.2
通讯作者：
Abbeduto, Leonard
中科院分区：
文献类型：
--
作者：
Finestack, Lizbeth H.;Sterling, Audra M.;Abbeduto, Leonard
本研究比较了唐氏综合征（DS）和脆性X染色体综合征（FXS）的言语表达儿童和青少年的接受性和表达性语言特征，并检查了这些特征可靠区分诊断组的程度。共有24名DS言语参与者（平均年龄：12岁），22名FXS言语参与者（平均年龄：12岁）和27名典型发展参与者（TD;平均年龄=4岁）完成了接受性和表达性词汇和语法的标准化测量，以及会话语言样本。研究结果表明，有不同的DS和FXS语言配置文件，其特点是语法能力的差异。诊断组没有根据词汇表现进行区分。这项研究支持与DS和FXS相关的独特语言配置文件的存在。
This study compared the receptive and expressive language profiles of verbally expressive children and adolescents with Down Syndrome (DS) and those with Fragile X syndrome (FXS) and examined the extent to which these profiles reliably differentiate the diagnostic groups. A total of twenty-four verbal participants with DS (mean age: 12 years), twenty-two verbal participants with FXS (mean age: 12 years), and twenty-seven participants with typical development (TD; mean age=4 years) completed standardized measures of receptive and expressive vocabulary and grammar, as well as a conversational language sample. Study results indicate that there are distinct DS and FXS language profiles, which are characterized by differences in grammatical ability. The diagnostic groups were not differentiated based on vocabulary performance. This study supports the existence of unique language profiles associated with DS and FXS.