Neural dynamics in response to binary taste mixtures
Neural dynamics in response to binary taste mixtures
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DOI：
10.1152/jn.00917.2012
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发表时间：
2013-04-01
影响因子：
2.5
通讯作者：
Katz, Donald B.
中科院分区：
文献类型：
--
作者：
Maier, Joost X.;Katz, Donald B.
Maier JX，Katz DB.二元味觉混合物的神经动力学响应。J Neurophysiol 109：2108-2117，2013.首次发表于2013年1月30日; doi：10.1152/jn.00917.2012.-在自然环境中遇到的味觉刺激通常是多种味素的组合。虽然我们对味觉系统中的神经元如何对单一的味觉刺激做出反应已经有了很多了解，但对大脑如何处理这种混合刺激却知之甚少。在这里，我们探测清醒大鼠初级味觉皮层（GC）的单个神经元对一系列味觉刺激的反应，这些刺激包括100%柠檬酸（100 mM）、100%氯化钠（100 mM）、100%蔗糖（100 mM）和一系列二元混合物（90/10、70/30、50/50、30/70和10/90%）。我们测试了三种不同的假设反应模式的存在：1）反应作为混合物中蔗糖（或酸）浓度的函数单调变化（“单调”模式）; 2）反应增加或减少作为刺激的混合程度的函数（“混合”模式）;以及3）从类似于一种纯味道突然改变为类似于另一种纯味道的反应（“分类”模式）。我们的研究结果表明，在GC神经元的反应单调和混合模式的存在。具体而言，进一步的分析（包括50 mM蔗糖和柠檬酸的存在）表明，混合物抑制可靠地先于适口性相关的模式。适口性相关模式的出现的时间动态平行的时间动态的偏好行为的出现，为相同的混合物作为测量的一个简短的访问测试。我们没有看到分类编码的证据。
Maier JX, Katz DB. Neural dynamics in response to binary taste mixtures. J Neurophysiol 109: 2108-2117, 2013. First published January 30, 2013; doi:10.1152/jn.00917.2012.-Taste stimuli encountered in the natural environment are usually combinations of multiple tastants. Although a great deal is known about how neurons in the taste system respond to single taste stimuli in isolation, less is known about how the brain deals with such mixture stimuli. Here, we probe the responses of single neurons in primary gustatory cortex (GC) of awake rats to an array of taste stimuli including 100% citric acid (100 mM), 100% sodium chloride (100 mM), 100% sucrose (100 mM), and a range of binary mixtures (90/10, 70/30, 50/50, 30/70, and 10/90%). We tested for the presence of three different hypothetical response patterns: 1) responses varying monotonically as a function of concentration of sucrose (or acid) in the mixture (the "monotonic" pattern); 2) responses increasing or decreasing as a function of degree of mixture of the stimulus (the "mixture" pattern); and 3) responses that change abruptly from being similar to one pure taste to being similar the other (the "categorical" pattern). Our results demonstrate the presence of both monotonic and mixture patterns within responses of GC neurons. Specifically, further analysis (that included the presentation of 50 mM sucrose and citric acid) made it clear that mixture suppression reliably precedes a palatability-related pattern. The temporal dynamics of the emergence of the palatability-related pattern parallel the temporal dynamics of the emergence of preference behavior for the same mixtures as measured by a brief access test. We saw no evidence of categorical coding.