Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis.
Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis.
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DOI：
10.2174/1874205x00802010051
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发表时间：
2008-09-12
期刊：
影响因子：
--
通讯作者：
Cudkowicz, Merit E
中科院分区：
文献类型：
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作者：
Qureshi, Muddasir;Brown, Robert H Jr;Rogers, Jack T;Cudkowicz, Merit E
金属毒性已被确定为肌萎缩侧索硬化症（ALS）和其他神经退行性疾病的可能危险因素。我们对在麻省总医院（MGH）就诊的321例ALS患者的尿液、头发和血液中的金属水平以及血清铁蛋白进行了回顾性图表回顾。我们发现，与公布的正常值相比，肌萎缩性脊髓硬化症患者的头发铅水平和血清铁蛋白水平升高。24小时尿液标本中砷、铅、汞、镉、铊、钴、铝等金属含量及血清中铅、汞、砷等金属含量均在正常范围内。我们的结论是，24小时尿液或血液金属测试不值得作为ALS评估的一部分。ALS人群血清铁蛋白水平升高可能反映了铁代谢的潜在扰动。
Metal toxicity has been identified as a possible risk factor for amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. We conducted a retrospective chart review of urinary, hair and blood metal levels and serum ferritin in 321 people with ALS seen over a ten-year period at the Massachusetts General Hospital (MGH). We found that hair lead levels and serum ferritin levels were elevated in ALS patients compared to published normal values. Metal levels of arsenic, lead, mercury, cadmium, thallium, cobalt and aluminum in 24-hour urine specimens and lead, mercury and arsenic in serum were within the normal range. We conclude that twenty-four hour urine or blood testing for metals is not warranted as part of the evaluation of ALS. Elevated levels of serum ferritin in ALS population could reflect an underlying perturbation in iron metabolism.