Prefrontal white matter in pathological liars.
Prefrontal white matter in pathological liars.
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DOI：
10.1192/bjp.187.4.320
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发表时间：
2005-10
期刊：
影响因子：
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通讯作者：
Yaling Yang;A. Raine;T. Lencz;S. Bihrle;L. Lacasse;P. Colletti
中科院分区：
文献类型：
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作者：
Yaling Yang;A. Raine;T. Lencz;S. Bihrle;L. Lacasse;P. Colletti
研究表明，正常人撒谎时前额叶皮层的双侧激活增加，但没有对撒谎者进行结构成像研究。目的评估欺诈者是否表现出前额叶灰质和白质体积的结构异常。方法采用结构磁共振成像技术对12名病理说谎、欺骗和欺骗（“说谎者”）、16名反社会对照组和21名正常对照组的人进行前额叶灰质和白质体积评估。结果与反社会对照组和正常对照组相比，说谎者的前额叶白质增加了22-26%，前额叶灰白色比减少了36-42%。结论：这些发现为说谎者的结构性脑缺陷提供了第一个证据，它们暗示前额叶皮层是说谎背后神经回路的一个重要（但不是唯一）组成部分，并提供了欺诈性人格的初步神经生物学关联。
BACKGROUND Studies have shown increased bilateral activation in the prefrontal cortex when normal individuals lie, but there have been no structural imaging studies of deceitful individuals. AIMS To assess whether deceitful individuals show structural abnormalities in prefrontal grey and white matter volume. METHOD Prefrontal grey and white matter volumes were assessed using structural magnetic resonance imaging in 12 individuals who pathologically lie, cheat and deceive ('liars'),16 antisocial controls and 21 normal controls. RESULTS Liars showed a 22-26% increase in prefrontal white matter and a 36-42% reduction in prefrontal grey/white ratios compared with both antisocial controls and normal controls. CONCLUSIONS These findings provide the first evidence of a structural brain deficitinliars, they implicate the prefrontal cortex as an important (but not sole) component in the neural circuitry underlying lying and provide an initial neurobiological correlate of a deceitful personality.