Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women
Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women
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DOI：
10.1210/jc.2005-0396
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发表时间：
2005-09-01
影响因子：
5.8
通讯作者：
Melton, LJ
中科院分区：
文献类型：
--
作者：
Khosla, S;Riggs, BL;Melton, LJ
内容：尽管雌激素在调节女性骨量方面明显起着核心作用，但对男性的研究表明，可能存在一个生物可利用（生物）雌二醇（E-2）阈值水平，低于该水平，老年男性开始骨质流失，皮质骨中雌激素缺乏的阈值可能远低于松质骨。目的：我们的目的是通过定量计算机断层扫描评估体积骨矿物质密度（vBMD）和骨几何形状，并将其与循环生物E-2和生物睾酮水平联系起来。设计：我们研究了235名女性的横断面，年龄分层人群样本结果：vBMD/结构参数与年轻绝经前妇女（年龄，20-39岁）的性类固醇水平无关，平均生物E-2水平为17 pg/ml（63 pmol/L）。相比之下，在中位生物E-2水平为3 pg/ml（11 pmol/L）的绝经后期妇女（年龄≥ 60岁）中，生物E-2和生物睾酮水平均与多个部位的骨小梁和皮质vBMD和皮质面积显著相关。晚期绝经前和早期绝经后妇女（年龄，40 - 59岁）的中间中位数生物E-2水平为11 pg/ ml（42 pmol/L）显示年龄调整相关性的生物E-2水平与骨小梁，但不与皮质vBMD.Conclusions：在妇女中，生物E-2水平与vBMD和一些结构骨参数在低，但不高生物E-2水平。与男性的研究结果相似，女性皮质骨中雌激素缺乏的阈值似乎低于骨小梁。
Context: Although estrogen clearly plays a central role in regulating bone mass in women, studies in men have suggested that there may be a threshold bioavailable (bio) estradiol (E-2) level below which aging men begin to lose bone and that the threshold for estrogen deficiency in cortical bone may be considerably lower than that in trabecular bone. There are no data testing this in women.Objective: Our objective was to assess volumetric bone mineral density (vBMD) and bone geometry by quantitative computed tomography and relate these to circulating bio E-2 and bio testosterone levels.Design: We studied a cross-sectional, age-stratified population sample of 235 women (age, 21-97 yr).Results: vBMD/structural parameters were not related to sex steroid levels in young premenopausal women (age, 20-39 yr) with a median bio E-2 level of 17 pg/ml (63 pmol/ liter). By contrast, bio E-2 and bio testosterone levels were both significantly associated with trabecular and cortical vBMD and cortical area at multiple sites in late postmenopausal women (age >= 60 yr) who had a median bio E-2 level of 3 pg/ml (11 pmol/ liter). Late premenopausal and early postmenopausal women ( age, 40 - 59 yr) with an intermediate median bio E-2 level of 11 pg/ ml (42 pmol/ liter) showed age-adjusted correlations of bio E-2 levels with trabecular but not with cortical vBMD.Conclusions: In women, bio E-2 levels are associated with vBMD and some structural bone parameters at low but not high bio E-2 levels. Similar to findings in men, the threshold for estrogen deficiency in cortical bone in women appears to be lower than that in trabecular bone.